A. salmonicida has become resistant to penicillin, tetracycline and erythromycin. It remains susceptible to chloramphenicol and aminoglycoside according to a publication from Romania  but another reference describes it as resistant to chloramphenicol and sulfonamides as well . The frequent use of quinolones undoubtedly contributed to the rapid development of resistance to this drug class. An attenuated live vaccine is available and widely used with good effect.
While considered non-pathogenic to humans, a recent case report from India describes a patient with positive blood cultures for A. salmonicida. The organism was sensitive to multiple antibiotics. Unfortunately, no history regarding exposure to fish is provided; the patient presented with a non-descript febrile illness which responded promptly to cefixime. Possible misidentification of A. salmonicida by automated bacterial identification systems (Vitek) make this case somewhat questionable.
By contrast, Vibrio salmonicida causes a septic disease.
 Vanden Bergh. http://www.proteomesci.com/content/11/1/42
 Giraud. J Med Microbiol 2004;. 58: 895