Cresemba / Isavuconazole:  Not Just Another Azole

It is amazing how modifications to the azole structure have produced ever more potent, ever more useful antifungals.  Ketoconazole had limited usability because of its many side effects related to off-target sterol synthesis inhibition, solubility (or lack thereof) and erratic Continue reading Cresemba / Isavuconazole:  Not Just Another Azole

Nikkomycins Are Finally Getting Some Respect

Besides azoles, candins and the polyene class of antifungals there is not much to select from when it comes to systemic fungal infections.  Until the recent arrival of voriconazole and posaconazole, infections caused by molds always required amphotericin B to Continue reading Nikkomycins Are Finally Getting Some Respect

The Amazing Sulfonamides

Sulfonamides really cover more infectious territory than most other antibiotics. Besides the more common bacterial species, they are active against many ‘special’ pathogens, like S. maltophilia, P. jiroveci, Listeria, Nocardia,, C. burneti (Q-fever), and T. whipplei (Whipple’s disease). Not to forget their use in Continue reading The Amazing Sulfonamides