Sulfonamides Revisited, With an Emphasis on Dapsone

The sulfonamide moiety is a remarkable structure giving rise to diverse drugs in arious therapeutic areas such as antibiotics, antidiabetics, diuretics and anti-inflammatory agents. In regards to antibiotics, sulfonamides are in common use as antifungals (P. jiroveci), antiparasitics (toxoplasmosis, cyclospora, isospora, Continue reading Sulfonamides Revisited, With an Emphasis on Dapsone

Strep Infections in High Places

George Washington, age 67,  had a bad peritonsillar or epiglottal abscess; indeed, he died from it as his personal physicians resorted to extensive blood letting and did not dare lance the abscess.  He would have recovered with penicillin, I guess, but in his Continue reading Strep Infections in High Places