There are numerous reasons why drugs get stuck in development. Certainly, problems with efficacy or problems with safety are main reasons but there are many other ‘derailers’ as well. For instance regulatory issues or manufacturing, difficulties can stop a program.
Continue reading Why Some Did Not Make It
Posted in Did you know...?, The Viewpoint |
Tagged Abbott, ABSSSI, Advanced Life Sciences, ALS, antibiotic blog, Arpida, Astellas, Basilea, Bayer, BMS, CABP, ceftobiprole, Cethromycin, Cubicin, Cubist, dalbavancin, Dalvance, daptomycin, Doribax, doripenem, Durata, Exulett, Factive, failed programs, failed studies, faropenem, FDA, garenoxacin, gatifloxacin, GCP, gemifloxacin, GSK, GSK ‘052, iclaprim, J&J, Ketek, linezolid, new guidelines, NI, oritavancin, Oscient, Pfizer, PhRMA, Replidyne, Restanza, Sanofi, Schering, Shionogi, Targanta, telavancin, telithromycin, Tequin, The Medicines Company, Theravance, tigecycline, TMC, Toyama, Tygacil, Vibativ, Vicuron, Wyeth, Zevtera |
Since the publication of a series of posters at ICAAC 2014, we finally know what’s hidden behind the ‘Carbavance’ name. ‘Carbavance’ stands for the combination of meropenem with the B-lactamase inhibitor RPX7009 which The Medicines Company (TMC) inlicensed from Rempex
Continue reading What’s in a Name? Would ‘Carbavance’ Still Smell as Sweet?
Posted in QIDP Antibiotics, The News, The Viewpoint |
Tagged AstraZeneca, AZ, biapenem, carbavance, FDA, meropenem, QIDP, Rempex, RPX2003, RPX2014, RPX7009, The Medicines Company, TMC |
Why are there so few boron-containing drugs on the market? The cancer drug bortezumib (Velcade®) may be the only better-known drug on the market with a boron atom in its structure. Among antibiotics, there is Kerydin™ (tavaborole), an approved topical
Continue reading Not So Boring: Boron-Containing Antibiotics Create a Stir
Posted in The News, The Viewpoint |
Tagged AN3365, Anacor, benzoxaborole, betalactamase inhibitor, boron antibiotics, bortezumib, carbavance, GSK ‘052, GSK2251052, Kerydin, onychomycosis, oxaborole, Rempex, RPX-7009, SCYN-7158, Scynexis, tavaborole, The Medicines Company, TMC, Trichophyton, trypanosomiasis, Velcade |