Dosis Sola Facit Venenum – The TAB08 (aka TGN1412) Relaunch

It is a while ago (2006) when TeGenero ran its ill-fated Phase 1 study of TGN-1412, a CD28 superagonist slated for studies in diseases like rheumatoid arthritis and B-cell CLL. Unexpectedly, in this FIM study, TGN1412 generated a cytokine release Continue reading Dosis Sola Facit Venenum – The TAB08 (aka TGN1412) Relaunch

Two New Approaches For Dealing with Sepsis / Toxemia

There is hardly an indication which has accumulated more failed clinical trials than the sepsis area.  Called first bacteremia, later sepsis, sepsis syndrome or septic shock, there have been numerous attempts to influence the cascade of events that eventually lead Continue reading Two New Approaches For Dealing with Sepsis / Toxemia