{"id":3174,"date":"2017-02-20T04:35:50","date_gmt":"2017-02-20T09:35:50","guid":{"rendered":"http:\/\/allphasepharma.com\/dir\/?p=3174"},"modified":"2025-09-20T19:12:37","modified_gmt":"2025-09-21T01:12:37","slug":"google-news-week-antibiotics","status":"publish","type":"post","link":"https:\/\/allphasepharma.com\/dir\/2017\/02\/20\/3174\/google-news-week-antibiotics\/","title":{"rendered":"Google Search for News on “Antibiotics”"},"content":{"rendered":"

\"\"<\/a><\/p>\n

The top-line news articles that come up on a Google search when one enters the term \u201cantibiotics\u201d is truly an eclectic bunch. Here is Page 1 of search results after eliminating some duplications. We have a few comments on these headlines for \u201cBreaking News\u201d.<\/p>\n

Antibiotics, not surgery, could treat appendicitis in children
\n<\/a>This article is based on a retrospective review of studies on the non-operative treatment for appendicitis. Instead of performing an appendectomy, antibiotics were administered. Complicated cases (perforation, abscess) were excluded. The literature search identified only 10 studies, providing a surprisingly small (N=413) sample size for analysis, and none of the studies were \u201chigh-quality\u201d. In general, various broad-spectrum antibiotics were administered, often in combination. The non-surgical patients did very well; initial antibiotic treatment appears effective (in 97% of cases) and safe. The authors conclude that surgery is probably not needed in most cases but – given the soft data situation – also add lots of caveats and disclaimers.<\/p>\n

With a common condition like appendicitis we should not have to rely on the findings from a small non-representative data set. There are approx. 250,000 cases of appendicitis in the US alone, most are referred to surgical therapy[1]<\/a>. The records collected by a Kaiser Permanente or other health care provider would be expected to have better and more complete data. Certainly their sample size would be significantly larger. In the absence of a prospective study, we are dealing with meta-analyses, either based on published literature or an insurer\u2019s data collection. With everything else being equal, larger is better in our opinion.<\/p>\n

Docs Prescribe\u00a0Antibiotics\u00a0If Patients Expect Them
\n<\/a>Not really a surprise! Wanting to oblige, or just to avoid lengthy discussions when the waiting room is full, this habit will die only slowly.<\/p>\n

Online pharmacies illegally handing out\u00a0antibiotics\u00a0are fuelling rise of superbugs
\n<\/a>This study was conducted in Great Britain. Some 50% of online pharmacies do good business with antibiotics without asking a lot of questions, some were not even registered to MHRA. However, the statement that this practice is \u2018fueling the rise of superbugs\u2019 is mere conjecture, an extrapolation not supported by the data. Likewise, one\u00a0could also state that this practice is \u2018fueling the obesity epidemic\u2019 as antibiotics are growth-promoters, not only in animals. Equally stupid.<\/p>\n

\"\"<\/a><\/p>\n

Synthetic\u00a0antibiotic\u00a0developed by Sask. researchers to combat drug-resistant bacteria
\n<\/a>Something new and semi-interesting: We are informed that phosphopyricin[2]<\/a>, a new synthetic antibiotic with a structure unlike any available class of compounds, has activity against MDR pathogens, a bactericidal MoA, and low toxicity in animal studies. Its structure (see figure) contains tungsten, the W atom (which stands for Wolfram in case you are interested). The spectrum of activity includes S. aureus and enterococci (both E. faecalis and E. faecium), with MICs in the 2-8 mg\/L range. Unfortunately, Pseudomonas or Acinetobacter are not susceptible. It is also a very light-sensitive compound and degrades easily in nature.<\/p>\n

Antibiotics\u00a0May Impair Cancer Immunotherapy
\n<\/a>A retrospective study of patients with metastatic RCC treated with immune checkpoint inhibitors PD-1 found an association between prior antibiotic use and a much reduced PFS time. Without a publication, this press release is just that \u2013 a press release.<\/p>\n

MSF Takes on\u00a0Antibiotic\u00a0Resistance
\n<\/a>Dealing with MDR infections in their patients is as difficult for MSF as it is for any other institution or referral center. Improving access to microbiology lab services is an urgent need for those who work on the frontlines.<\/p>\n

Do You Really Need to Finish All Your\u00a0Antibiotics?
\n<\/a>We will have a separate blog about the topic of \u2018duration of antibiotic therapy\u2019 coming out soon.<\/p>\n

Antibiotics\u00a0After Sex Nearly Halves Incidence of STIs
\n<\/a>Good to know. Actually, we knew that already, so thanks for reminding us.<\/p>\n

Slim pickings for news-worthy news, I’d say. \u00a0Although\u00a0this was not a representative sample and there are some (964,000 – 10) more links to check,\u00a0we lost interest after Page 1. Sorry!<\/p>\n

Abbreviations
\n<\/strong>MHRA\u00a0\u00a0 Medicines and Healthcare Products Regulatory Agency \/ Britain
\nMSF\u00a0\u00a0\u00a0\u00a0\u00a0 Medecins sans frontiers \u2013 doctors without borders
\nPD-1\u00a0\u00a0\u00a0\u00a0\u00a0 programmed cell death protein 1
\nPFS\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 progression-free survival
\nRCC\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 renal cell carcinoma
\nSTI\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 sexually transmitted infections<\/p>\n

 <\/p>\n

References<\/strong>:
\n[1]<\/a> Deng, Y. (2010). Seasonal and day of the week variations of perforated appendicitis in US children. Pediatr Surg Int, 26: 691
\n[2]<\/a> pentacarbonyl(diphenyl(3-pyrrole)phosphane)tungsten<\/p>\n","protected":false},"excerpt":{"rendered":"

The top-line news articles that come up on a Google search when one enters the term \u201cantibiotics\u201d is truly an eclectic bunch. Here is Page 1 of search results after eliminating some duplications. We have a few comments on these headlines for \u201cBreaking News\u201d. Antibiotics, not surgery, could treat appendicitis Continue reading Google Search for News on “Antibiotics”<\/span>→<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":3179,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":true,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[227,3,18],"tags":[1271,403,1971,1583,1967,1965,1968,1969,1966,1970],"class_list":["post-3174","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recent_literature","category-the_news","category-the_viewpoint","tag-allphase-pharma-consulting","tag-antibiotic-blog","tag-google-search-antibiotics","tag-harald-reinhart","tag-msf-and-resistant-infections","tag-new-antibiotic","tag-pfs-reduced-by-antibiotics","tag-phosphopyrocin","tag-treatment-of-appendicitis","tag-tungsten"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2017\/02\/Google-Slider-blog.jpg?fit=642%2C180&ssl=1","jetpack_shortlink":"https:\/\/wp.me\/p4KWFr-Pc","jetpack_sharing_enabled":true,"jetpack-related-posts":[{"id":2084,"url":"https:\/\/allphasepharma.com\/dir\/2015\/10\/28\/2084\/making-the-news-something-hilarious-something-ominous\/","url_meta":{"origin":3174,"position":0},"title":"Making The News: \u00a0Something Hilarious, Something Ominous…","author":"Harald","date":"October 28, 2015","format":false,"excerpt":"Hilarious: \u00a0Chicks and Kids Antibiotic use in animals is defended as infection prophylaxis, but the honest reason why chickens are exposed for most days of their short life to antibiotics of various kinds is for growth promotion.\u00a0 Antibiotic use keeps those chicks healthy which in turn makes them eat more\u2026","rel":"","context":"In "Recent Literature"","block_context":{"text":"Recent Literature","link":"https:\/\/allphasepharma.com\/dir\/category\/recent_literature\/"},"img":{"alt_text":"Hilarious - slider copy","src":"https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2015\/10\/Hilarious-slider-copy.jpg?resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2015\/10\/Hilarious-slider-copy.jpg?resize=350%2C200 1x, https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2015\/10\/Hilarious-slider-copy.jpg?resize=525%2C300 1.5x"},"classes":[]},{"id":157,"url":"https:\/\/allphasepharma.com\/dir\/2014\/04\/22\/157\/antibiotics-with-qidp-designation\/","url_meta":{"origin":3174,"position":1},"title":"Antibiotics with QIDP Designation – – – Updated 9-30-14","author":"Harald","date":"April 22, 2014","format":false,"excerpt":"For the latest QIDP listing, please click HERE \u00a0 Since\u00a0FDA issued the QIDP designation in 2012, many companies have requested this important 'label'. \u00a0Which should not come as a surprise: QIDP status confers significant benefits - and there is no downside. 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