Sulfonamides really cover more infectious territory than most other antibiotics. Besides the more common bacterial species, they are\u00a0active\u00a0against many ‘special’ pathogens, like S. maltophilia,\u00a0P. jiroveci, Listeria, Nocardia,, C. burneti (Q-fever), and T. whipplei (Whipple’s disease). Not to forget their\u00a0use in malaria, toxoplasmosis, \u00a0melioidosis, cyclospora, and atypical mycobacterial infections.
\nThen there is brucellosis and paracoccidioidomycosis.Paracocci? \u00a0Yes. South American blastomycosis is often treated with sulfa medications, with equal efficacy as seen with itraconazole.
\nSo, with P. jiroveci, this is yet\u00a0another fungal infections for which to consider sulfonamides. Amazingly, sulfonamide derivatives have also shown activity against more common fungi like Candida, Aspergillus, and even Fusarium [1]. \u00a0However, these compounds are still at the lab stage.<\/p>\n
[1] Chohan. \u00a0Transition Met Chem (2009) 34:153\u2013161<\/p>\n","protected":false},"excerpt":{"rendered":"
Sulfonamides really cover more infectious territory than most other antibiotics. Besides the more common bacterial species, they are\u00a0active\u00a0against many ‘special’ pathogens, like S. maltophilia,\u00a0P. jiroveci, Listeria, Nocardia,, C. burneti (Q-fever), and T. whipplei (Whipple’s disease). Not to forget their\u00a0use in malaria, toxoplasmosis, \u00a0melioidosis, cyclospora, and atypical mycobacterial infections. Then there Continue reading The Amazing Sulfonamides<\/span>