{"id":534,"date":"2014-07-06T18:23:31","date_gmt":"2014-07-06T18:23:31","guid":{"rendered":"http:\/\/allphasepharma.com\/dir\/?p=534"},"modified":"2014-08-31T16:16:42","modified_gmt":"2014-08-31T20:16:42","slug":"pleuromutilins-are-important-to-control-brachyspira-hyodysenteriae","status":"publish","type":"post","link":"https:\/\/allphasepharma.com\/dir\/2014\/07\/06\/534\/pleuromutilins-are-important-to-control-brachyspira-hyodysenteriae\/","title":{"rendered":"Pleuromutilins Are Important to Control Brachyspira hyodysenteriae"},"content":{"rendered":"

Spirochetal colitis or swine dysentery is a disease of piglets with worldwide distribution.\u00a0 It can cause severe bloody diarrheal disease with a mortality of up to 50% in herds if untreated and thus can have great economic impact.\u00a0 The disease has been nearly eradicated in the US but periodically outbreaks still occur albeit rarely.\"Pass_the_pigs_dice\"<\/a><\/p>\n

<\/p>\n

An asymptomatic carrier pig can infect a herd but mice may also carry B.hyodysenteriae and be the source of a local epidemic.\u00a0 Diagnosis is not always easy but the organism can be isolated from rectal \/ fecal cultures.\u00a0 B. hyodysenteriae is an anaerobic hemolysin-producing spirochete.<\/p>\n

Treatment consists of rehydration and antibiotics like carbadox, lincomycin, the pleuromutilins tiamulin and valnemulin, or tylvalocin (a macrolide).[1] \u00a0Carbadox is now banned in many countries because of its carcinogenic potential.[2]\u00a0\u00a0 Drug resistance has become an issue and pleuromutilins are often necessary as a last resort.\u00a0 However, of great concern are recent\u00a0reports of B.hyodysenteriae with increased MICs to tiamulin.[3] [4]<\/p>\n

Unlike other Brachyspira species, B. h. has not associated been associated with human disease.<\/p>\n

P.S.\u00a0 for the philhellenes \/ \u03c6\u03b9\u03bb\u03ad\u03bb\u03bb\u03b7\u03bd\u03b5\u03c2 \u00a0among you: hys (gen: hyos) = pig !<\/p>\n

\n

References:<\/strong><\/p>\n

[1] http:\/\/vetmed.iastate.edu\/vdpam\/new-vdpam-employees\/food-supply-veterinary-medicine\/swine\/swine-diseases\/swine-dysentery
\n[2] http:\/\/en.wikipedia.org\/wiki\/Carbadox
\n[3] van Duijkeren<\/a>. J Antimicrob Chemother.<\/a>\u00a02014 May 3. [Epub]
\n[4] http:\/\/www.thepigsite.com\/articles\/4507\/mic-results-of-brachyspira-hyodysenteriae-strains-recently-isolated-swine-dysentery-outbreaks-in-south-and-south-east-brazil<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Spirochetal colitis or swine dysentery is a disease of piglets with worldwide distribution.\u00a0 It can cause severe bloody diarrheal disease with a mortality of up to 50% in herds if untreated and thus can have great economic impact.\u00a0 The disease has been nearly eradicated in the US but periodically outbreaks Continue reading Pleuromutilins Are Important to Control Brachyspira hyodysenteriae<\/span>→<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[140],"tags":[403,267,268,223,271,117,270,248,272,269],"class_list":["post-534","post","type-post","status-publish","format-standard","hentry","category-interesting_facts","tag-antibiotic-blog","tag-brachyspira-hyodysenteriae","tag-carbadox","tag-macrolide","tag-pig-dysentery","tag-pleuromutilin","tag-spirochetal-colitis","tag-tiamulin","tag-tylvalosin","tag-valnemulin"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_shortlink":"https:\/\/wp.me\/p4KWFr-8C","jetpack_sharing_enabled":true,"jetpack-related-posts":[{"id":949,"url":"https:\/\/allphasepharma.com\/dir\/2014\/09\/28\/949\/african-swine-fever-epidemics-in-russia\/","url_meta":{"origin":534,"position":0},"title":"African Swine Fever Epidemics in Russia","author":"Harald","date":"September 28, 2014","format":false,"excerpt":"You are excused if \u201cPig Progress\u201d or \"The Pig Site\" are\u00a0not journals on your regular reading list.\u00a0 So, you may not have heard about the massive recent culling of swine in Russia in response to outbreaks of ASF (African swine fever).\u00a0 ASF is a severe hemorrhagic disease associated with mortality\u2026","rel":"","context":"In "Did you know...?"","block_context":{"text":"Did you know...?","link":"https:\/\/allphasepharma.com\/dir\/category\/interesting_facts\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2014\/09\/ASF-slider.jpg?fit=640%2C200&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2014\/09\/ASF-slider.jpg?fit=640%2C200&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2014\/09\/ASF-slider.jpg?fit=640%2C200&ssl=1&resize=525%2C300 1.5x"},"classes":[]},{"id":4540,"url":"https:\/\/allphasepharma.com\/dir\/2025\/06\/21\/4540\/nanobodies-for-autoimmune-diseases\/","url_meta":{"origin":534,"position":1},"title":"NANOBODIES FOR AUTOIMMUNE DISEASES","author":"Harald","date":"June 21, 2025","format":false,"excerpt":"Thrombotic thrombocytopenic purpura (TTP) is a devastating disease with a downhill course of neurologic, renal and cardiac complications leading to death at a young age if untreated.\u00a0 Thrombocytopenia and thrombosis are its hallmark, with fever, anemia and neurologic deficits. It is caused by large aggregates of vWF, a protein which\u2026","rel":"","context":"In "Recent Literature"","block_context":{"text":"Recent Literature","link":"https:\/\/allphasepharma.com\/dir\/category\/recent_literature\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2025\/06\/image-1.jpeg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2025\/06\/image-1.jpeg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2025\/06\/image-1.jpeg?resize=525%2C300&ssl=1 1.5x"},"classes":[]},{"id":3195,"url":"https:\/\/allphasepharma.com\/dir\/2017\/02\/28\/3195\/cmv-connections-paul-bunnell-negative-mononucleosis-changelings\/","url_meta":{"origin":534,"position":2},"title":"CMV Connections: Paul-Bunnell Negative Mononucleosis and \u2018Changelings\u2019","author":"Harald","date":"February 28, 2017","format":false,"excerpt":"Mononuclesosis is an EBV infection that can be diagnosed with the heterophil antibody test developed by Paul and Bunnell. The test is based on the agglutination of sheep erythrocytes with the blood of EBV infected patients. P-B heterophil serology is negative in \u2018mononucleosis\u2019 caused by CMV. In this day and\u2026","rel":"","context":"In "Did you know...?"","block_context":{"text":"Did you know...?","link":"https:\/\/allphasepharma.com\/dir\/category\/interesting_facts\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2017\/02\/CMV-connections-slider.jpg?resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2017\/02\/CMV-connections-slider.jpg?resize=350%2C200 1x, https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2017\/02\/CMV-connections-slider.jpg?resize=525%2C300 1.5x"},"classes":[]},{"id":517,"url":"https:\/\/allphasepharma.com\/dir\/2014\/07\/05\/517\/bc-3781-passes-phase-2-with-flying-colors-readies-for-phase-3\/","url_meta":{"origin":534,"position":3},"title":"BC-3781 Passes Phase 2 with Flying Colors, Readies for Phase 3","author":"Harald","date":"July 5, 2014","format":false,"excerpt":"The pleuromutilins are a relatively \u2018old\u2019 class of antibiotics that have seen much use in veterinary but not in human medicine.\u00a0 According to EMA, Tiamulin is an \u201cessential antibiotic\u201d for the control of dysentery in pigs which is caused by Brachyspira hyodysenteriae, a macrolide-resistant pathogen.[1]\u00a0 Retapamulin \/ Altabax\u00ae was introduced\u2026","rel":"","context":"In "QIDP Antibiotics"","block_context":{"text":"QIDP Antibiotics","link":"https:\/\/allphasepharma.com\/dir\/category\/qidp_antibiotic\/"},"img":{"alt_text":"pleuromutilin1","src":"http:\/\/allphasepharma.com\/dir\/wp-content\/uploads\/2014\/07\/pleuromutilin1.jpe","width":350,"height":200},"classes":[]},{"id":876,"url":"https:\/\/allphasepharma.com\/dir\/2014\/09\/13\/876\/actinomycosis-in-kangaroos\/","url_meta":{"origin":534,"position":4},"title":"Actinomycosis in Kangaroos","author":"Harald","date":"September 13, 2014","format":false,"excerpt":"Actinomycosis of the jaw (\u201clumpy jaw\u201d) may be the most common infectious disease in kangaroos and wallabies.\u00a0 While also seen in wild kangaroos, it is much more common in zoo animals, presumably because commonly provided grass feed can lead to\u00a0gum disease thus providing a nidus for infection.\u00a0 The organism, always\u2026","rel":"","context":"In "Did you know...?"","block_context":{"text":"Did you know...?","link":"https:\/\/allphasepharma.com\/dir\/category\/interesting_facts\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2014\/09\/Kangaroo-slider.jpg?fit=640%2C200&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2014\/09\/Kangaroo-slider.jpg?fit=640%2C200&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2014\/09\/Kangaroo-slider.jpg?fit=640%2C200&ssl=1&resize=525%2C300 1.5x"},"classes":[]},{"id":2157,"url":"https:\/\/allphasepharma.com\/dir\/2015\/12\/03\/2157\/there-is-momentum-building-for-rsv-therapeutics\/","url_meta":{"origin":534,"position":5},"title":"There is Momentum Building for RSV Therapeutics","author":"Harald","date":"December 3, 2015","format":false,"excerpt":"Sometimes \u2013 for no obvious reason \u2013 there is a flurry of publications from a particular area which has been quiet for a long time.\u00a0 RSV is such an area where new drug development had a hard time getting started.\u00a0 There was always the lure of big money: an infection\u2026","rel":"","context":"In "Recent Literature"","block_context":{"text":"Recent Literature","link":"https:\/\/allphasepharma.com\/dir\/category\/recent_literature\/"},"img":{"alt_text":"RSV - 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