{"id":550,"date":"2014-07-08T19:51:51","date_gmt":"2014-07-08T19:51:51","guid":{"rendered":"http:\/\/allphasepharma.com\/dir\/?p=550"},"modified":"2014-08-31T16:15:54","modified_gmt":"2014-08-31T20:15:54","slug":"sars-and-mers-a-comparison-of-the-new-corona-viruses","status":"publish","type":"post","link":"https:\/\/allphasepharma.com\/dir\/2014\/07\/08\/550\/sars-and-mers-a-comparison-of-the-new-corona-viruses\/","title":{"rendered":"SARS and MERS \u2013 a Comparison of the New Corona Viruses"},"content":{"rendered":"<p>This compilation is from many sources and necessarily incomplete as we still have lots to learn about MERS. Please come back periodically for updated information.<a href=\"https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2014\/07\/SARS%2BMERS.jpg?ssl=1\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-559\" src=\"https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2014\/07\/SARS%2BMERS.jpg?resize=530%2C677&#038;ssl=1\" alt=\"SARS+MERS\" width=\"530\" height=\"677\" srcset=\"https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2014\/07\/SARS%2BMERS.jpg?w=642&amp;ssl=1 642w, https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2014\/07\/SARS%2BMERS.jpg?resize=234%2C300&amp;ssl=1 234w\" sizes=\"auto, (max-width: 530px) 100vw, 530px\" \/><\/a><\/p>\n<p>Status: 7\/8\/2014<\/p>\n<p>Some tidbits of unknown significance:<\/p>\n<ul>\n<li>A close relative of MERS-CoV is carried by the European hedgehog (Erinaceus europaeus).\u00a0 As many children have hedgehogs as pets in Germany and elsewhere without getting sick, this corona virus seems rather benign for humans.<\/li>\n<li>HCoV also have neuroinvasive and immunostimulatory properties.\u00a0 Some SARS related proteins stimulate local interferon and cytokine production.<\/li>\n<li>Cyclophilin inhibitors like cyclosporine may have antiviral activity against HCoV like they have against HIV and HCV.<\/li>\n<\/ul>\n<p><strong>References:<br \/>\n<\/strong>For genome structure, Coleman has a great comparative schematic [1],<br \/>\nVirology Tidbids has good information as well.[2].<\/p>\n<p>[1] Coleman.\u00a0 Journal of Virology; 88: 5209; 2014<br \/>\n[2] http:\/\/virologytidbits.blogspot.com\/2014\/04\/sars-cov-v-mers-cov-differences-and.html<br \/>\n[3] ACE = angiotensin-converting enzyme<br \/>\n[4] Aded<span style=\"color: #000000;\">eji. <a href=\"http:\/\/www.sciencedirect.com\/science\/journal\/18796257\"><span style=\"color: #000000;\">Current Opinion in Virology<\/span><\/a> 8: 45; 2014<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>This compilation is from many sources and necessarily incomplete as we still have lots to learn about MERS. Please come back periodically for updated information. Status: 7\/8\/2014 Some tidbits of unknown significance: A close relative of MERS-CoV is carried by the European hedgehog (Erinaceus europaeus).\u00a0 As many children have hedgehogs <a class=\"more-link\" href=\"https:\/\/allphasepharma.com\/dir\/2014\/07\/08\/550\/sars-and-mers-a-comparison-of-the-new-corona-viruses\/\">Continue reading <span class=\"screen-reader-text\">  SARS and MERS \u2013 a Comparison of the New Corona Viruses<\/span><span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[227,3],"tags":[403,275,279,280,282,423,281,277,273,274,276],"class_list":["post-550","post","type-post","status-publish","format-standard","hentry","category-recent_literature","category-the_news","tag-antibiotic-blog","tag-comparison","tag-cyclophilin","tag-cyclosporin","tag-disease","tag-emerging-infections","tag-epidemiology","tag-genomics","tag-mers","tag-sars","tag-virology"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_shortlink":"https:\/\/wp.me\/p4KWFr-8S","jetpack_sharing_enabled":true,"jetpack-related-posts":[{"id":3550,"url":"https:\/\/allphasepharma.com\/dir\/2020\/02\/09\/3550\/some-thoughts-about-the-new-coronavirus-syndrome-and-its-transmission\/","url_meta":{"origin":550,"position":0},"title":"Some Thoughts about the New Coronavirus Syndrome and its Transmission","author":"Harald","date":"February 9, 2020","format":false,"excerpt":"First and upfront, let\u2019s call this virus WARS*, which stands for Wuhan Associated Respiratory Syndrome.\u00a0 President Xi Jingping called for a war against the new virus, and a war it is.\u00a0 Therefore our acronym makes intuitive sense.\u00a0 The naming of new viruses is getting politized and silly: yes, we need\u2026","rel":"","context":"In &quot;The News&quot;","block_context":{"text":"The News","link":"https:\/\/allphasepharma.com\/dir\/category\/the_news\/"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":708,"url":"https:\/\/allphasepharma.com\/dir\/2014\/08\/09\/708\/did-you-know-that\/","url_meta":{"origin":550,"position":1},"title":"Did you know that\u2026","author":"Harald","date":"August 9, 2014","format":false,"excerpt":"A Phase 1 study evaluating tigecycline (Tygacil\u00ae) to treat refractory Acute Myeloid Leukemia is currently underway? [1] Niacin extended release tablets (nicotinic acid, Niaspan\u00ae) was associated with a significantly higher rate of infections (appendicitis, bronchitis, cellulitis) compared to placebo in the AIM-HIGH trial which enrolled over 3400 patients? [2] Macrolides\u2026","rel":"","context":"In &quot;Did you know...?&quot;","block_context":{"text":"Did you know...?","link":"https:\/\/allphasepharma.com\/dir\/category\/interesting_facts\/"},"img":{"alt_text":"","src":"http:\/\/allphasepharma.com\/dir\/wp-content\/uploads\/2014\/08\/jpg","width":350,"height":200},"classes":[]},{"id":885,"url":"https:\/\/allphasepharma.com\/dir\/2014\/09\/17\/885\/new-pathogens-outbreaks-epidemics-2014\/","url_meta":{"origin":550,"position":2},"title":"Bugs and Outbreaks That Scared Us in 2014","author":"Harald","date":"September 17, 2014","format":false,"excerpt":"At the end of every year, some of us tally \u2013 in a retrospective \u2013 the most remarkable epidemics, newly recognized pathogens or resistance issues that occupied the headlines in the past 12 months.\u00a0 Here a sneak preview what you are likely to see in the coming December issue of\u2026","rel":"","context":"In &quot;The Viewpoint&quot;","block_context":{"text":"The Viewpoint","link":"https:\/\/allphasepharma.com\/dir\/category\/the_viewpoint\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2014\/09\/Outbreak.gif?fit=638%2C230&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2014\/09\/Outbreak.gif?fit=638%2C230&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2014\/09\/Outbreak.gif?fit=638%2C230&ssl=1&resize=525%2C300 1.5x"},"classes":[]},{"id":4416,"url":"https:\/\/allphasepharma.com\/dir\/2025\/05\/30\/4416\/baff-april-inhibitors-homing-in-on-igan\/","url_meta":{"origin":550,"position":3},"title":"BAFF \/ APRIL Inhibitors Homing in on IgAN","author":"Harald","date":"May 30, 2025","format":false,"excerpt":"Today we discuss the group of BAFF\/APRIL inhibitors, specifically the three TACI mAb constructs that are currently in development. They were tested in a broad gamut of B-cell indications but failed to show efficacy in many. So far, consistent clinical success has been seen only in IgA nephropathy (IgAN), with\u2026","rel":"","context":"In &quot;Recent Literature&quot;","block_context":{"text":"Recent Literature","link":"https:\/\/allphasepharma.com\/dir\/category\/recent_literature\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2025\/05\/HR-BLOG-BAFF-APRIL.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2025\/05\/HR-BLOG-BAFF-APRIL.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2025\/05\/HR-BLOG-BAFF-APRIL.jpg?resize=525%2C300&ssl=1 1.5x"},"classes":[]},{"id":5735,"url":"https:\/\/allphasepharma.com\/dir\/2025\/11\/08\/5735\/comparison-of-baff-april-inhibitors-2\/","url_meta":{"origin":550,"position":4},"title":"COMPARISON OF BAFF \/ APRIL INHIBITORS \u2013 2","author":"Harald","date":"November 8, 2025","format":false,"excerpt":"Shortly after posting our last blog on tacicepts, new data was published in the NEJM on the pivotal Phase 3 trial of atacicept.\u00a0 This publication by Lafayette et al. provides results from an IA of the ongoing ORIGIN-3 trial.[1] \u00a0We updated our table with this new information that centers on\u2026","rel":"","context":"In &quot;Recent Literature&quot;","block_context":{"text":"Recent Literature","link":"https:\/\/allphasepharma.com\/dir\/category\/recent_literature\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2025\/11\/atacicept-ORIGIN-3-Interim-e1762657582817.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2025\/11\/atacicept-ORIGIN-3-Interim-e1762657582817.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2025\/11\/atacicept-ORIGIN-3-Interim-e1762657582817.jpg?resize=525%2C300&ssl=1 1.5x"},"classes":[]},{"id":2186,"url":"https:\/\/allphasepharma.com\/dir\/2015\/12\/19\/2186\/aztreonam-plus-avibactam-a-new-bright-star-in-the-night-sky\/","url_meta":{"origin":550,"position":5},"title":"Aztreonam PLUS Avibactam \u2013 A New Bright Star in the Night Sky","author":"Harald","date":"December 19, 2015","format":false,"excerpt":"Looking at the molecular structure of ceftazidime (CTAZ) and aztreonam (ATM), the differences are clear, and so are the similarities: ATM does not have the cephem ring structure of CTAZ, only the 4-member beta-lactam ring.\u00a0 However, the side chains are identical in both CTAZ and ATM which explains the overlapping\u2026","rel":"","context":"In &quot;Recent Literature&quot;","block_context":{"text":"Recent Literature","link":"https:\/\/allphasepharma.com\/dir\/category\/recent_literature\/"},"img":{"alt_text":"Avibactam - slider","src":"https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2015\/12\/Avibactam-slider.jpg?resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2015\/12\/Avibactam-slider.jpg?resize=350%2C200 1x, https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2015\/12\/Avibactam-slider.jpg?resize=525%2C300 1.5x, https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2015\/12\/Avibactam-slider.jpg?resize=700%2C400 2x"},"classes":[]}],"jetpack_likes_enabled":true,"_links":{"self":[{"href":"https:\/\/allphasepharma.com\/dir\/wp-json\/wp\/v2\/posts\/550","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/allphasepharma.com\/dir\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/allphasepharma.com\/dir\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/allphasepharma.com\/dir\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/allphasepharma.com\/dir\/wp-json\/wp\/v2\/comments?post=550"}],"version-history":[{"count":5,"href":"https:\/\/allphasepharma.com\/dir\/wp-json\/wp\/v2\/posts\/550\/revisions"}],"predecessor-version":[{"id":810,"href":"https:\/\/allphasepharma.com\/dir\/wp-json\/wp\/v2\/posts\/550\/revisions\/810"}],"wp:attachment":[{"href":"https:\/\/allphasepharma.com\/dir\/wp-json\/wp\/v2\/media?parent=550"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/allphasepharma.com\/dir\/wp-json\/wp\/v2\/categories?post=550"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/allphasepharma.com\/dir\/wp-json\/wp\/v2\/tags?post=550"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}