{"id":608,"date":"2014-07-15T11:00:47","date_gmt":"2014-07-15T15:00:47","guid":{"rendered":"http:\/\/allphasepharma.com\/dir\/?p=608"},"modified":"2014-08-31T16:12:51","modified_gmt":"2014-08-31T20:12:51","slug":"surprise-hanta-virus-right-in-your-back-yard","status":"publish","type":"post","link":"https:\/\/allphasepharma.com\/dir\/2014\/07\/15\/608\/surprise-hanta-virus-right-in-your-back-yard\/","title":{"rendered":"Surprise: Hanta Virus Right in Your Back Yard"},"content":{"rendered":"<p>Hanta Virus Epidemics in Germany?<\/p>\n<p>When I learned that a friend of mine came down with Hanta virus infection in Germany, I thought I had heard wrong.<\/p>\n<p>Mice and voles shed hanta viruses in their excreta which &#8211; when aerosolized and inhaled &#8211; can cause significant disease.\u00a0 In some parts of Germany, it is Puumala, in others the Dobrava-Belgrade virus. \u00a0In 2012, over 2800 cases were diagnosed in Germany alone [1]. This emerging infection is no longer so infrequent after all.<div class=\"simplePullQuote right\"><p><span style=\"color: #000000\">Voles can have large population fluctuations from 14 to 500 voles per acre<br \/>\n<span style=\"font-size: 8pt\">FUN FACTS ABOUT THE VOLE\u00a0\u00a0[4]<\/span><\/span><\/p>\n<\/div><!--more--><\/p>\n<p>Initial clinical symptoms are high fever, headache, backaches, and thrombopenia +\/- purpura which may lead to a hematologic work-up.\u00a0 Cases may progress to \u201cnephropathia endemica\u201d, characterized by oliguria and hematuria.\u00a0 Rarely, shock or organ failure may ensue.<\/p>\n<p>Hence, the term \u201cHFRS\u201d (Hemorrhagic Fever with Renal Syndrome) summarizes the clinical features well.<\/p>\n<p>Fortunately, unlike Sin Nombre virus cardiopulmonary syndrome, mortality is low. \u00a0The disease runs its course with complete recovery in almost all cases. \u00a0Still, it is not a benign affair: While recognizing reporting bias towards severe cases, a 55-65% hospitalization rate and 5% rate for temporary dialysis shows that this is not a trivial\u00a0viral disease [2].<\/p>\n<p>Exposure is from\u00a0outdoors activities.\u00a0 The lovely little bank voles love to nest in forested areas at the edge of towns.\u00a0 Right were you live&#8230;.<\/p>\n<figure id=\"attachment_609\" aria-describedby=\"caption-attachment-609\" style=\"width: 357px\" class=\"wp-caption alignright\"><a href=\"https:\/\/allphasepharma.com\/dir\/wp-content\/uploads\/2014\/07\/bank-vole.jpe\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-609\" src=\"https:\/\/allphasepharma.com\/dir\/wp-content\/uploads\/2014\/07\/bank-vole.jpe\" alt=\"No, it's not a camel this time...\" width=\"357\" height=\"237\" \/><\/a><figcaption id=\"caption-attachment-609\" class=\"wp-caption-text\">Bank vole (no, it&#8217;s not a camel this time&#8230;)<\/figcaption><\/figure>\n<p>Epidemics occur mainly in winter and spring, in a 2-3 year rhythm.<\/p>\n<p>Diagnosis is by serology.<\/p>\n<p>Treatment is purely symptomatic.\u00a0 There is no vaccine yet but progress is being made and a Phase 2 study is underway [3].<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<p><strong>References:<\/strong><\/p>\n<p>[1] Krueger.\u00a0 Dtsch Arztebl Int.110: 27; 2013<br \/>\n[2] \u00a0Krautkr\u00e4mer. \u00a0Kidney International (2012) 82, 1243<br \/>\n[3]\u00a0<span style=\"font-weight: normal; color: #000000;\">A Phase 2a Randomized, Double-Blind, Dose-Optimizing Study to Evaluate the Immunogenicity of Hantaan\/Puumala Virus DNA Vaccine. \u00a0http:\/\/clinicaltrials.gov\/show\/NCT02116205<br \/>\n[4]\u00a0http:\/\/www.thejunglestore.com\/Voles<\/span><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hanta Virus Epidemics in Germany? When I learned that a friend of mine came down with Hanta virus infection in Germany, I thought I had heard wrong. Mice and voles shed hanta viruses in their excreta which &#8211; when aerosolized and inhaled &#8211; can cause significant disease.\u00a0 In some parts <a class=\"more-link\" href=\"https:\/\/allphasepharma.com\/dir\/2014\/07\/15\/608\/surprise-hanta-virus-right-in-your-back-yard\/\">Continue reading <span class=\"screen-reader-text\">  Surprise: Hanta Virus Right in Your Back Yard<\/span><span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[140,3],"tags":[403,317,324,318,315,322,321,325,316,326,323,257,320],"class_list":["post-608","post","type-post","status-publish","format-standard","hentry","category-interesting_facts","category-the_news","tag-antibiotic-blog","tag-dobrava-belgrade","tag-four-corners-virus","tag-germany","tag-hanta-virus","tag-hfrs","tag-mouse","tag-nephropathia-epidemica","tag-puumala","tag-renal-failure","tag-sin-nombre-virus","tag-vaccine","tag-vole"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_shortlink":"https:\/\/wp.me\/p4KWFr-9O","jetpack_sharing_enabled":true,"jetpack-related-posts":[{"id":661,"url":"https:\/\/allphasepharma.com\/dir\/2014\/07\/31\/661\/ebola-fact-sheet\/","url_meta":{"origin":608,"position":0},"title":"Ebola \u2013 Fact Sheet    (Updated 10\/3\/2014)","author":"Harald","date":"July 31, 2014","format":false,"excerpt":"The WHO just released the latest statistics on what has turned into the largest ever outbreak of Ebola virus (EBOV) in Africa.\u00a0 The epidemic started in Guinea around\u00a0December 2013. As of 7\/27\/2014, Guinea, Liberia, Nigeria, and Sierra Leone have reported a total of 1323 cases, with 729 fatalities [i].\u00a0 Most\u2026","rel":"","context":"In &quot;The News&quot;","block_context":{"text":"The News","link":"https:\/\/allphasepharma.com\/dir\/category\/the_news\/"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":550,"url":"https:\/\/allphasepharma.com\/dir\/2014\/07\/08\/550\/sars-and-mers-a-comparison-of-the-new-corona-viruses\/","url_meta":{"origin":608,"position":1},"title":"SARS and MERS \u2013 a Comparison of the New Corona Viruses","author":"Harald","date":"July 8, 2014","format":false,"excerpt":"This compilation is from many sources and necessarily incomplete as we still have lots to learn about MERS. Please come back periodically for updated information. Status: 7\/8\/2014 Some tidbits of unknown significance: A close relative of MERS-CoV is carried by the European hedgehog (Erinaceus europaeus).\u00a0 As many children have hedgehogs\u2026","rel":"","context":"In &quot;Recent Literature&quot;","block_context":{"text":"Recent Literature","link":"https:\/\/allphasepharma.com\/dir\/category\/recent_literature\/"},"img":{"alt_text":"SARS+MERS","src":"https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2014\/07\/SARS%2BMERS.jpg?resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2014\/07\/SARS%2BMERS.jpg?resize=350%2C200 1x, https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2014\/07\/SARS%2BMERS.jpg?resize=525%2C300 1.5x"},"classes":[]},{"id":885,"url":"https:\/\/allphasepharma.com\/dir\/2014\/09\/17\/885\/new-pathogens-outbreaks-epidemics-2014\/","url_meta":{"origin":608,"position":2},"title":"Bugs and Outbreaks That Scared Us in 2014","author":"Harald","date":"September 17, 2014","format":false,"excerpt":"At the end of every year, some of us tally \u2013 in a retrospective \u2013 the most remarkable epidemics, newly recognized pathogens or resistance issues that occupied the headlines in the past 12 months.\u00a0 Here a sneak preview what you are likely to see in the coming December issue of\u2026","rel":"","context":"In &quot;The Viewpoint&quot;","block_context":{"text":"The Viewpoint","link":"https:\/\/allphasepharma.com\/dir\/category\/the_viewpoint\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2014\/09\/Outbreak.gif?fit=638%2C230&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2014\/09\/Outbreak.gif?fit=638%2C230&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2014\/09\/Outbreak.gif?fit=638%2C230&ssl=1&resize=525%2C300 1.5x"},"classes":[]},{"id":3550,"url":"https:\/\/allphasepharma.com\/dir\/2020\/02\/09\/3550\/some-thoughts-about-the-new-coronavirus-syndrome-and-its-transmission\/","url_meta":{"origin":608,"position":3},"title":"Some Thoughts about the New Coronavirus Syndrome and its Transmission","author":"Harald","date":"February 9, 2020","format":false,"excerpt":"First and upfront, let\u2019s call this virus WARS*, which stands for Wuhan Associated Respiratory Syndrome.\u00a0 President Xi Jingping called for a war against the new virus, and a war it is.\u00a0 Therefore our acronym makes intuitive sense.\u00a0 The naming of new viruses is getting politized and silly: yes, we need\u2026","rel":"","context":"In &quot;The News&quot;","block_context":{"text":"The News","link":"https:\/\/allphasepharma.com\/dir\/category\/the_news\/"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":1470,"url":"https:\/\/allphasepharma.com\/dir\/2015\/05\/21\/1470\/vaccine-mismatch-the-influenza-season-2014-2015\/","url_meta":{"origin":608,"position":4},"title":"Vaccine Mismatch \u2013 The Influenza Season 2014 \/ 2015","author":"Harald","date":"May 21, 2015","format":false,"excerpt":"PLEASE SHARE YOUR OPINION AND VOTE\u00a0BELOW \u00a0 It has\u00a0always been a bit of a gamble: Predicting the main circulating flu types and subtypes for the next season based on information from the previous season is an educated guess. \u00a0It works well most of the time but fails when there is\u2026","rel":"","context":"In &quot;Recent Literature&quot;","block_context":{"text":"Recent Literature","link":"https:\/\/allphasepharma.com\/dir\/category\/recent_literature\/"},"img":{"alt_text":"2003 Vaccine Effectiveness","src":"https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2015\/05\/2003-Vaccine-Effectiveness.jpg?resize=350%2C200","width":350,"height":200},"classes":[]},{"id":949,"url":"https:\/\/allphasepharma.com\/dir\/2014\/09\/28\/949\/african-swine-fever-epidemics-in-russia\/","url_meta":{"origin":608,"position":5},"title":"African Swine Fever Epidemics in Russia","author":"Harald","date":"September 28, 2014","format":false,"excerpt":"You are excused if \u201cPig Progress\u201d or \"The Pig Site\" are\u00a0not journals on your regular reading list.\u00a0 So, you may not have heard about the massive recent culling of swine in Russia in response to outbreaks of ASF (African swine fever).\u00a0 ASF is a severe hemorrhagic disease associated with mortality\u2026","rel":"","context":"In &quot;Did you know...?&quot;","block_context":{"text":"Did you know...?","link":"https:\/\/allphasepharma.com\/dir\/category\/interesting_facts\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2014\/09\/ASF-slider.jpg?fit=640%2C200&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2014\/09\/ASF-slider.jpg?fit=640%2C200&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2014\/09\/ASF-slider.jpg?fit=640%2C200&ssl=1&resize=525%2C300 1.5x"},"classes":[]}],"jetpack_likes_enabled":true,"_links":{"self":[{"href":"https:\/\/allphasepharma.com\/dir\/wp-json\/wp\/v2\/posts\/608","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/allphasepharma.com\/dir\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/allphasepharma.com\/dir\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/allphasepharma.com\/dir\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/allphasepharma.com\/dir\/wp-json\/wp\/v2\/comments?post=608"}],"version-history":[{"count":9,"href":"https:\/\/allphasepharma.com\/dir\/wp-json\/wp\/v2\/posts\/608\/revisions"}],"predecessor-version":[{"id":806,"href":"https:\/\/allphasepharma.com\/dir\/wp-json\/wp\/v2\/posts\/608\/revisions\/806"}],"wp:attachment":[{"href":"https:\/\/allphasepharma.com\/dir\/wp-json\/wp\/v2\/media?parent=608"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/allphasepharma.com\/dir\/wp-json\/wp\/v2\/categories?post=608"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/allphasepharma.com\/dir\/wp-json\/wp\/v2\/tags?post=608"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}