{"id":7037,"date":"2026-04-20T22:15:23","date_gmt":"2026-04-21T04:15:23","guid":{"rendered":"https:\/\/allphasepharma.com\/dir\/?p=7037"},"modified":"2026-04-20T22:21:33","modified_gmt":"2026-04-21T04:21:33","slug":"new-biomarker-consortium-pros","status":"publish","type":"post","link":"https:\/\/allphasepharma.com\/dir\/2026\/04\/20\/7037\/new-biomarker-consortium-pros\/","title":{"rendered":"New BIOMARKER CONSORTIUM PROs"},"content":{"rendered":"
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Aulus Cornelius Celsus wrote his famous book ‘De Medicina’ approximately 2000 years ago.  Living in the times of Caesar Augustus, little is known about his persona.  We are not even sure whether he was a practicing physician.  Many of his books were lost but Volume VIII was rediscovered in the early renaissance, around the year 1426 [1]<\/a>.  A few copies survived, mostly incomplete.<\/p>\n\n\n

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A C Celsus – De Medicina<\/figcaption><\/figure>\n<\/div>\n\n\n

Celsus described tissue reactions to insults in terms of dolor, calor, rubor, and tumor, ie., pain, warmth, redness and swelling.  This tetrad quite adequately describes the signs and symptoms of inflammation. Calor locally is warmth, and systemically would equal fever. The term \u2018functio laesa\u2019, or \u2018functional impairment\u2019, is often added.<\/p>\n\n\n\n

Fast forward to 2026: The Biomarker Consortium, with contributions from FDA, NIH, CMS, FNIH and others, released a publication entitled ’20 years of advancing precision medicine’ [2]<\/a>,[3]<\/a>.  Among other therapeutic areas the Consortium worked on, were several infectious disease projects (ABSSSI, CABP, VABP) with the goal of developing PROs for these infections.<\/p>\n\n\n\n

The Consortium developed 2 tools, called PNEUMO PRO\u00a9<\/sup> and SKINFECT PRO\u00a9<\/sup> which can be reviewed online [4]<\/a>.<\/p>\n\n\n\n

Time and space do not allow us to dig into both tools; suffice it to introduce SKINFECT PRO\u00a9<\/sup> here, a PRO tool that allows patients to record symptoms every day using a 1-to-5 scoring system of symptoms. We no longer track 4 (four) but rather a whole slew of complaints:<\/p>\n\n\n

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