{"id":722,"date":"2014-08-15T21:40:29","date_gmt":"2014-08-16T01:40:29","guid":{"rendered":"http:\/\/allphasepharma.com\/dir\/?p=722"},"modified":"2014-10-16T16:45:45","modified_gmt":"2014-10-16T20:45:45","slug":"some-curious-tidbits","status":"publish","type":"post","link":"https:\/\/allphasepharma.com\/dir\/2014\/08\/15\/722\/some-curious-tidbits\/","title":{"rendered":"Some Curious Tidbits"},"content":{"rendered":"<p>Were you aware\u00a0that&#8230;<\/p>\n<ul>\n<li>there is also an amphotericin <strong>A<\/strong> which has antifungal properties? \u00a0It has a broader spectrum but is much less potent than Amphotericin B and therefore not being used. [1]<\/li>\n<li>in 1946, the first truly randomized and partially\u00a0blinded study was started in Britain under the leadership of the Medical Research Council comparing streptomycin to placebo in the treatment of culture-proven pulmonary TB? [2]\n<dl id=\"attachment_730\" class=\"wp-caption alignright\" style=\"width: 207px;\">\n<dt class=\"wp-caption-dt\"><a href=\"https:\/\/allphasepharma.com\/dir\/wp-content\/uploads\/2014\/08\/Placebo.jpe\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-730 size-full\" src=\"https:\/\/allphasepharma.com\/dir\/wp-content\/uploads\/2014\/08\/Placebo.jpe\" alt=\"Is it Active or Placebo?\" width=\"197\" height=\"255\" \/><\/a>Active Drug &#8211; or Placebo?<\/dt>\n<\/dl>\n<\/li>\n<li>tetracyclines are used to good effect in onchocerciasis and other filarial diseases? \u00a0The worms are totally dependent on\u00a0Wolbachia bacteria for reproduction, and doxycycline therapy effectively shuts down the generation of\u00a0microfiliaria. [3]<\/li>\n<li>bones of ancient Nubians were found to contain\u00a0high\u00a0amounts of tetracyclines? \u00a0Anthropologists\u00a0believe the source may be\u00a0beer brewed with grain containing Streptomycetes, consumed by Nubians at\u00a0an early age already. [4]<\/li>\n<\/ul>\n<hr \/>\n<p><strong>REFERENCES:<br \/>\n<\/strong>[1] \u00a0 Halde. \u00a0Journal of Investigative Dermatology<span style=\"color: #000000;\">\u00a01957;\u00a0<\/span><b style=\"color: #000000;\">28:\u00a0<\/b><span style=\"color: #000000;\">\u00a0217<br \/>\n<\/span>[2] \u00a0 Crofton. \u00a0<span style=\"color: #000000;\">J R Soc Med. Oct 2006; 99: 531<br \/>\n<\/span>[3] \u00a0 Pfarr. \u00a0Mini-Reviews in Medicinal Chemistry, 2006; 6: 203<br \/>\n[4] \u00a0Basset. Science 1980; 209: 1532<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Were you aware\u00a0that&#8230; there is also an amphotericin A which has antifungal properties? \u00a0It has a broader spectrum but is much less potent than Amphotericin B and therefore not being used. [1] in 1946, the first truly randomized and partially\u00a0blinded study was started in Britain under the leadership of the <a class=\"more-link\" href=\"https:\/\/allphasepharma.com\/dir\/2014\/08\/15\/722\/some-curious-tidbits\/\">Continue reading <span class=\"screen-reader-text\">  Some Curious Tidbits<\/span><span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":730,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[140],"tags":[470,471,427,474,472,477,475,476,263,473],"class_list":["post-722","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-interesting_facts","tag-amphotericin-a","tag-amphotericin-b","tag-doxycycline","tag-filariasis","tag-mrc-streptomycin-trial","tag-nubian-bone","tag-onchocerciasis","tag-streptomycete","tag-tetracycline","tag-wolbachia"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/allphasepharma.com\/dir\/wp-content\/uploads\/2014\/08\/Placebo.jpe","jetpack_shortlink":"https:\/\/wp.me\/p4KWFr-bE","jetpack_sharing_enabled":true,"jetpack-related-posts":[{"id":1722,"url":"https:\/\/allphasepharma.com\/dir\/2015\/07\/15\/1722\/streptomyces-the-industrious-antibiotic-producer\/","url_meta":{"origin":722,"position":0},"title":"Streptomyces \u2013 The Industrious Antibiotic Producer","author":"Harald","date":"July 15, 2015","format":false,"excerpt":"Like other\u00a0actinomycetes, the Streptomyces group of microbes straddles the somewhat artificial boundary between bacteria and fungi.\u00a0Growth on culture plates looks 'fungal' and the organism produces spores and germtubes that look like mycelia.\u00a0 Nonetheless these soil organisms are bacteria and of great interest to microbiologists as the producers of many antibiotics\u2026","rel":"","context":"In &quot;Did you know...?&quot;","block_context":{"text":"Did you know...?","link":"https:\/\/allphasepharma.com\/dir\/category\/interesting_facts\/"},"img":{"alt_text":"Streptomyces slider-2 copy","src":"https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2015\/07\/Streptomyces-slider-2-copy.jpg?resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2015\/07\/Streptomyces-slider-2-copy.jpg?resize=350%2C200 1x, https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2015\/07\/Streptomyces-slider-2-copy.jpg?resize=525%2C300 1.5x"},"classes":[]},{"id":1969,"url":"https:\/\/allphasepharma.com\/dir\/2015\/09\/29\/1969\/two-new-antifungals-presented-at-icaac-san-diego\/","url_meta":{"origin":722,"position":1},"title":"Two New Antifungals Presented at ICAAC San Diego","author":"Harald","date":"September 29, 2015","format":false,"excerpt":"As noticed by many other colleagues, ICAAC 2015 was a shadow of its former self.\u00a0 Few participants overall, fewer posters, and even fewer exhibitors. \u00a0Reviewing the posters, there were relatively\u00a0few from industry, most came from university or small research labs.\u00a0 In a way, ICAAC 2015 was a true reflection of\u2026","rel":"","context":"In &quot;QIDP Antibiotics&quot;","block_context":{"text":"QIDP Antibiotics","link":"https:\/\/allphasepharma.com\/dir\/category\/qidp_antibiotic\/"},"img":{"alt_text":"ICAAC 2015 slider","src":"https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2015\/09\/ICAAC-2015-slider.jpg?resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2015\/09\/ICAAC-2015-slider.jpg?resize=350%2C200 1x, https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2015\/09\/ICAAC-2015-slider.jpg?resize=525%2C300 1.5x"},"classes":[]},{"id":2396,"url":"https:\/\/allphasepharma.com\/dir\/2016\/03\/23\/2396\/the-cresemba-candidemia-gamble-rien-ne-va-plus\/","url_meta":{"origin":722,"position":2},"title":"The Cresemba Candidemia Gamble \u2013 Rien Ne Va Plus","author":"Harald","date":"March 23, 2016","format":false,"excerpt":"Isavuconazole is a potent triazole; like Voriconazole, it has garnered an indication for invasive aspergillosis. However, it failed where other azole antifungals succeeded: in a pivotal trial, not yet published, the drug was inferior to Caspofungin in the treatment of invasive candidiasis\/candidemia in non-neutropenic patients\u00a0[1]. To provide some background: in\u2026","rel":"","context":"In &quot;QIDP Antibiotics&quot;","block_context":{"text":"QIDP Antibiotics","link":"https:\/\/allphasepharma.com\/dir\/category\/qidp_antibiotic\/"},"img":{"alt_text":"Crescemba Gamble copy","src":"https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2016\/03\/Crescemba-Gamble-copy.jpg?resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2016\/03\/Crescemba-Gamble-copy.jpg?resize=350%2C200 1x, https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2016\/03\/Crescemba-Gamble-copy.jpg?resize=525%2C300 1.5x"},"classes":[]},{"id":1079,"url":"https:\/\/allphasepharma.com\/dir\/2014\/10\/16\/1079\/nikkomycins-are-finally-getting-some-respect\/","url_meta":{"origin":722,"position":3},"title":"Nikkomycins Are Finally Getting Some Respect","author":"Harald","date":"October 16, 2014","format":false,"excerpt":"Besides azoles, candins and the polyene class of antifungals there is not much to select from when it comes to systemic fungal infections.\u00a0 Until the recent arrival of voriconazole and posaconazole, infections caused by molds always required amphotericin B to control.\u00a0 Only for Candida several good treatments exist on the\u2026","rel":"","context":"In &quot;QIDP Antibiotics&quot;","block_context":{"text":"QIDP Antibiotics","link":"https:\/\/allphasepharma.com\/dir\/category\/qidp_antibiotic\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2014\/10\/cocci-slider.jpg?fit=640%2C200&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2014\/10\/cocci-slider.jpg?fit=640%2C200&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2014\/10\/cocci-slider.jpg?fit=640%2C200&ssl=1&resize=525%2C300 1.5x"},"classes":[]},{"id":2205,"url":"https:\/\/allphasepharma.com\/dir\/2015\/12\/23\/2205\/qidp-antibiotics-2015-year-end-update\/","url_meta":{"origin":722,"position":4},"title":"QIDP Antibiotics  &#8211;  2015 Year-End Update","author":"Harald","date":"December 23, 2015","format":false,"excerpt":"Here an updated listing of all QIDP drugs we are aware of as of 12\/24\/2015. Today just\u00a0facts and numbers; we will provide an interpretation of the current landscape in upcoming blogs. There are\u00a058 drugs which garnered QIDP status and these are listed in the Main Table below. With the recent\u2026","rel":"","context":"In &quot;QIDP Antibiotics&quot;","block_context":{"text":"QIDP Antibiotics","link":"https:\/\/allphasepharma.com\/dir\/category\/qidp_antibiotic\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2015\/12\/QIDP-slider.jpg?fit=640%2C200&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2015\/12\/QIDP-slider.jpg?fit=640%2C200&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2015\/12\/QIDP-slider.jpg?fit=640%2C200&ssl=1&resize=525%2C300 1.5x"},"classes":[]},{"id":5392,"url":"https:\/\/allphasepharma.com\/dir\/2025\/09\/22\/5392\/olorofim-in-a-tight-spot\/","url_meta":{"origin":722,"position":5},"title":"OLOROFIM in a TIGHT SPOT","author":"Harald","date":"September 22, 2025","format":false,"excerpt":"Regulatory and development status of Olorofim, a novel antifungal.","rel":"","context":"In &quot;Recent Literature&quot;","block_context":{"text":"Recent Literature","link":"https:\/\/allphasepharma.com\/dir\/category\/recent_literature\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2025\/09\/Picture3-1.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2025\/09\/Picture3-1.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2025\/09\/Picture3-1.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2025\/09\/Picture3-1.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2025\/09\/Picture3-1.jpg?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2025\/09\/Picture3-1.jpg?resize=1400%2C800&ssl=1 4x"},"classes":[]}],"jetpack_likes_enabled":true,"_links":{"self":[{"href":"https:\/\/allphasepharma.com\/dir\/wp-json\/wp\/v2\/posts\/722","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/allphasepharma.com\/dir\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/allphasepharma.com\/dir\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/allphasepharma.com\/dir\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/allphasepharma.com\/dir\/wp-json\/wp\/v2\/comments?post=722"}],"version-history":[{"count":11,"href":"https:\/\/allphasepharma.com\/dir\/wp-json\/wp\/v2\/posts\/722\/revisions"}],"predecessor-version":[{"id":1090,"href":"https:\/\/allphasepharma.com\/dir\/wp-json\/wp\/v2\/posts\/722\/revisions\/1090"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/allphasepharma.com\/dir\/wp-json\/wp\/v2\/media\/730"}],"wp:attachment":[{"href":"https:\/\/allphasepharma.com\/dir\/wp-json\/wp\/v2\/media?parent=722"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/allphasepharma.com\/dir\/wp-json\/wp\/v2\/categories?post=722"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/allphasepharma.com\/dir\/wp-json\/wp\/v2\/tags?post=722"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}