{"id":876,"date":"2014-09-13T18:59:25","date_gmt":"2014-09-13T22:59:25","guid":{"rendered":"http:\/\/allphasepharma.com\/dir\/?p=876"},"modified":"2014-09-26T15:47:13","modified_gmt":"2014-09-26T19:47:13","slug":"actinomycosis-in-kangaroos","status":"publish","type":"post","link":"https:\/\/allphasepharma.com\/dir\/2014\/09\/13\/876\/actinomycosis-in-kangaroos\/","title":{"rendered":"Actinomycosis in Kangaroos"},"content":{"rendered":"<p><del><\/del>Actinomycosis of the jaw (\u201clumpy jaw\u201d) may be the most common infectious disease in <a href=\"https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2014\/09\/kangaroo-e1410648870932.gif?ssl=1\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\"alignright size-full wp-image-878\" src=\"https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2014\/09\/kangaroo-e1410648870932.gif?resize=200%2C203&#038;ssl=1\" alt=\"kangaroo\" width=\"200\" height=\"203\" \/><\/a>kangaroos and wallabies.\u00a0 While also seen in wild kangaroos, it is much more common in zoo animals, presumably because commonly provided grass feed can lead to\u00a0gum disease thus providing a nidus for infection.\u00a0 The organism, always present in the oral cavity as part of the normal mouth flora, penetrates into deeper layers and causes destruction of local tissues and bone. \u00a0\u00a0<!--more--><\/p>\n<p>Importantly, the infection interferes with the \u2018molar progression\u2019 whereby teeth migrate from the back towards the front of the mouth, which is the normal process of tooth eruption and dental renewal in kangaroos <a href=\"#_ftn1\" name=\"_ftnref1\">[1]<\/a>.<\/p>\n<p>There is still some confusion whether the fairly aggressive disease\u00a0 &#8211; it can present as local destructive disease but also with bacteremia which is often fatal &#8211; is actually caused by actionmyces alone or in concert with other mouth pathogen.\u00a0 Diagnosis based on stains of the lesion cannot definitively differentiate actinomyces from nocardia or fusobacteria, all pathogens often found in the oral cavity together.<a href=\"#_ftn2\" name=\"_ftnref2\">[2]<\/a>\u00a0 Hence, a synergistic infection with\u00a0several bacteria may be responsible.<\/p>\n<p><strong>\u00a0References:\u00a0<\/strong><\/p>\n<p><a href=\"#_ftnref1\" name=\"_ftn1\">[1]<\/a> http:\/\/www.2ndchance.info\/raisepossum-Johnson-Delaney2006.pdf<\/p>\n<p><a href=\"#_ftnref2\" name=\"_ftn2\">[2]<\/a> P Ladds.\u00a0 Pathology of Australian Native Wildlife.\u00a0\u00a0 Csiro Publishing 2009<br \/>\nhttp:\/\/books.google.com\/books?id=CR-MEFTR0PMC&#038;pg=PT169&#038;lpg=PT169&#038;dq=kangaroo+actinomycosis&#038;source=bl&#038;ots=frGwrZ603L&#038;sig=tAnfLydQAygwNRy-OtzL4HTZHL4&#038;hl=en&#038;sa=X&#038;ei=2jgPVJi4KOa1sQSNkIGoAw&#038;ved=0CDEQ6AEwAzgK#v=onepage&#038;q=kangaroo%20actinomycosis&#038;f=false<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Actinomycosis of the jaw (\u201clumpy jaw\u201d) may be the most common infectious disease in kangaroos and wallabies.\u00a0 While also seen in wild kangaroos, it is much more common in zoo animals, presumably because commonly provided grass feed can lead to\u00a0gum disease thus providing a nidus for infection.\u00a0 The organism, always <a class=\"more-link\" href=\"https:\/\/allphasepharma.com\/dir\/2014\/09\/13\/876\/actinomycosis-in-kangaroos\/\">Continue reading <span class=\"screen-reader-text\">  Actinomycosis in Kangaroos<\/span><span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":948,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[140],"tags":[538,540,536,537,539,541],"class_list":["post-876","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-interesting_facts","tag-actinomycosis","tag-fusobacterium","tag-kangaroo","tag-lumpy-jaw","tag-nocardia","tag-wallaby"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2014\/09\/Kangaroo-slider.jpg?fit=640%2C200&ssl=1","jetpack_shortlink":"https:\/\/wp.me\/p4KWFr-e8","jetpack_sharing_enabled":true,"jetpack-related-posts":[{"id":3195,"url":"https:\/\/allphasepharma.com\/dir\/2017\/02\/28\/3195\/cmv-connections-paul-bunnell-negative-mononucleosis-changelings\/","url_meta":{"origin":876,"position":0},"title":"CMV Connections: Paul-Bunnell Negative Mononucleosis and \u2018Changelings\u2019","author":"Harald","date":"February 28, 2017","format":false,"excerpt":"Mononuclesosis is an EBV infection that can be diagnosed with the heterophil antibody test developed by Paul and Bunnell. The test is based on the agglutination of sheep erythrocytes with the blood of EBV infected patients. P-B heterophil serology is negative in \u2018mononucleosis\u2019 caused by CMV. In this day and\u2026","rel":"","context":"In &quot;Did you know...?&quot;","block_context":{"text":"Did you know...?","link":"https:\/\/allphasepharma.com\/dir\/category\/interesting_facts\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2017\/02\/CMV-connections-slider.jpg?resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2017\/02\/CMV-connections-slider.jpg?resize=350%2C200 1x, https:\/\/i0.wp.com\/allphasepharma.com\/dir\/wp-content\/uploads\/2017\/02\/CMV-connections-slider.jpg?resize=525%2C300 1.5x"},"classes":[]},{"id":661,"url":"https:\/\/allphasepharma.com\/dir\/2014\/07\/31\/661\/ebola-fact-sheet\/","url_meta":{"origin":876,"position":1},"title":"Ebola \u2013 Fact Sheet    (Updated 10\/3\/2014)","author":"Harald","date":"July 31, 2014","format":false,"excerpt":"The WHO just released the latest statistics on what has turned into the largest ever outbreak of Ebola virus (EBOV) in Africa.\u00a0 The epidemic started in Guinea around\u00a0December 2013. As of 7\/27\/2014, Guinea, Liberia, Nigeria, and Sierra Leone have reported a total of 1323 cases, with 729 fatalities [i].\u00a0 Most\u2026","rel":"","context":"In &quot;The News&quot;","block_context":{"text":"The News","link":"https:\/\/allphasepharma.com\/dir\/category\/the_news\/"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":222,"url":"https:\/\/allphasepharma.com\/dir\/2014\/05\/30\/222\/hiv-therapy-guidance-recommendations-diverge-show-us-bias\/","url_meta":{"origin":876,"position":2},"title":"HIV Therapy Guidance Recommendations Diverge, Show US Bias","author":"Harald","date":"May 30, 2014","format":false,"excerpt":"US doctors seem to be very willing to start drugs earlier in disease, while their EU colleagues are slower and more conservative.\u00a0 Recent examples: the ever-wider indication for statins, the disproportionate uptake of drugs for attention-deficit \/ hyperactivity and opioids for pain relief.\u00a0 The new US HIV treatment guidelines are\u2026","rel":"","context":"In &quot;The Viewpoint&quot;","block_context":{"text":"The Viewpoint","link":"https:\/\/allphasepharma.com\/dir\/category\/the_viewpoint\/"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":608,"url":"https:\/\/allphasepharma.com\/dir\/2014\/07\/15\/608\/surprise-hanta-virus-right-in-your-back-yard\/","url_meta":{"origin":876,"position":3},"title":"Surprise: Hanta Virus Right in Your Back Yard","author":"Harald","date":"July 15, 2014","format":false,"excerpt":"Hanta Virus Epidemics in Germany? When I learned that a friend of mine came down with Hanta virus infection in Germany, I thought I had heard wrong. Mice and voles shed hanta viruses in their excreta which - when aerosolized and inhaled - can cause significant disease.\u00a0 In some parts\u2026","rel":"","context":"In &quot;Did you know...?&quot;","block_context":{"text":"Did you know...?","link":"https:\/\/allphasepharma.com\/dir\/category\/interesting_facts\/"},"img":{"alt_text":"No, it's not a camel this time...","src":"http:\/\/allphasepharma.com\/dir\/wp-content\/uploads\/2014\/07\/bank-vole.jpe","width":350,"height":200},"classes":[]},{"id":2955,"url":"https:\/\/allphasepharma.com\/dir\/2016\/12\/22\/2955\/aerosolized-antibiotics-part-2-disappointing-news-fronts\/","url_meta":{"origin":876,"position":4},"title":"Aerosolized Antibiotics (Part 2) \u2013 Mixed News on Two Fronts","author":"Harald","date":"December 22, 2016","format":false,"excerpt":"INSMED - NTM The company that is developing Arikayce, a preparation of liposomal amikacin inhalation (LAI), for the treatment of NTM had to withdraw its MAA in Europe earlier this year\u00a0[1] because data was not convincing enough for regulators to approve the application. 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