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Tag Archives: Amitiza

Trial Pains Secondary to Placebo Effect?

Posted on June 9, 2014 by Harald — No Comments ↓

An interesting report has just been published showing that Naloxegol is beneficial in OIC [i].  Naloxegol is a µ opioid receptor (MOR) antagonist which – by virtue of pegylation – acts peripherally and not centrally.  Hence, the analgesic effects of opioid therapy are unaffected while the very bothersome side effect Continue reading Trial Pains Secondary to Placebo Effect?→

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Posted in The Viewpoint | Tagged alvimopan, Amitiza, enrollment dynamics, Entereg, FDA Guidance, lubiprostone, MOR antagonist, Movantik, naloxegol, OIC, opioid side effect, opioid-induced constipation, peripheral opioid antagonist, Phase 3, placebo effect, SBM, study size | Leave a reply
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