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In 1886, Weil published detailed case descriptions of 4 patients with icterus, splenic enlargement and nephritis [1]. All four patients presented with acute onset of fever, elevated liver function tests (LFTs), hepatic enlargement, splenomegaly, and proteinuria. Two cases were recorded more than12 years earlier, but the author felt that they Continue reading On Leptospirosis (Weil’s Disease)
The 1st edition of Mandell’s textbook ‘Principles and Practice of Infectious Disease’ was published in 1979. It has grown ever since in size and numbers of chapters. Now in its 10th edition, it is and remains an impressive publication, a 2-volume set, a comprehensive reference textbook, kept up-to-date with periodic Continue reading Where are the Chloramphenicol Derivatives?
The early work on the organism and the toxoid vaccine reads like the ‘Who Is Who’ of microbiology: Klebs, Loeffler, Koch, Roux, Yersin, Behring, Kitasato, Schick, and T. Smith were all involved in bringing this deadly disease under control. In those days bacteria and diseases were referred to by the Continue reading About DIPHTHERIA