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Connections: From Mima/Herellea to Acinetobacter to the Double Helix to Lwoff to … CRAB

Posted on May 8, 2017 by Harald — No Comments ↓

There once was a Scientific American section authored by science historian James Burke called ‘Connections”. In it James Burke, a true renaissance man, showed us how an ‘internet’ of serendipitous encounters, connections between persons, places and events led to advances Continue reading Connections: From Mima/Herellea to Acinetobacter to the Double Helix to Lwoff to … CRAB→

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Posted in Did you know...? | Tagged Acinetobacter taxonomy, Andre Lwoff, antibiotic blog, bacteriophage, Beijerinck, CRAB, Feynman, H.P.R. Seeliger, Harald Reinhart, Jacob, James Burke, James Watson, L. seeligeri, Lingelsheimia, Listeria, lysogeny, Mima/Herellea, Monod, Moraxella, Nobel Prize, Paul Baumann, Scientific American, The Double Helix, von Lingelsheim | Leave a reply

CMV Connections: Paul-Bunnell Negative Mononucleosis and ‘Changelings’

Posted on February 28, 2017 by Harald — 1 Comment ↓

Mononuclesosis is an EBV infection that can be diagnosed with the heterophil antibody test developed by Paul and Bunnell. The test is based on the agglutination of sheep erythrocytes with the blood of EBV infected patients. P-B heterophil serology is Continue reading CMV Connections: Paul-Bunnell Negative Mononucleosis and ‘Changelings’→

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Posted in Did you know...? | Tagged ANP, antibiotic blog, atrial natriuretic peptide, balg etymology, CAD, changeling, chlamydia, CMV, CMV coronary angiitis, CMV enteritis, CMV hepatitis, CMV in pregnancy, CMV pneumonia, CMV prophylaxis, CMV retinitis, congenital CMV, EBV, Forssman antigen, GvHD, hand surgery, Harald Reinhart, helicobacter, heterophil antibody, lithotrypsy, neurosensory hearing loss, neurotropism, Nobel Prize, Paul-Bunnel test, Sauerbruch, Stanley Plotkin, Sterling Bunnell, valganciclovir, VZV, wechselbalg, Werner Forssman | 1 Reply

Prospecting for New Antibiotics

Posted on November 25, 2016 by Harald — No Comments ↓

The QIDP designation was introduced in 2012 to incentivize drug development in antiinfectives. QIDP came with several attractive features, such as prolongation of patent life, FDA expedited review and more. In addition, FDA made it quite easy to garner the label. Continue reading Prospecting for New Antibiotics→

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Posted in Did you know...?, QIDP Antibiotics, The News, The Viewpoint | Tagged AAI-101, ACH-975, Adhaogen, Affinium, antibiotic blog, antibiotic pipeline, AstraZeneca, Chiron, Crestone, Debiopharm, Entasis, ETX-0914, FabI, FDA, FtsZ, GSK, GSK-2140944, GSK-2251052, Harald Reinhart, LpxC inhibitor, MAT-2501, Matinas, MCB-3837, Morphochem, moxifloxacin, Novartis, novel MoA, novel MoA antibiotics, oxaquin, PDF inhibitor, pull incentive, push-pull incentive, QIDP, systemically active QIDP antibiotics, Taxis Pharma, topoisomerase II inhibitor, tRNA synthase inhibitor, TXA-709 | Leave a reply

Sulfonamides Revisited, With an Emphasis on Dapsone

Posted on October 6, 2016 by Harald — No Comments ↓

The sulfonamide moiety is a remarkable structure giving rise to diverse drugs in arious therapeutic areas such as antibiotics, antidiabetics, diuretics and anti-inflammatory agents. In regards to antibiotics, sulfonamides are in common use as antifungals (P. jiroveci), antiparasitics (toxoplasmosis, cyclospora, isospora, Continue reading Sulfonamides Revisited, With an Emphasis on Dapsone→

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Posted in Did you know...?, Recent Literature | Tagged acne, Allphase Pharma Consulting, antibiotic blog, aspirin, autoimmune diseases, Bayer, celiac disease, DADPS, dapsone, Dermatitis herpetiformis, Domagk, gluten enteropathy, Harald Reinhart, Lapdap, leprosy, Madura foot, malaria, methemoglobinemia, PCP, pemphigus, Prontosil, sulfapyridine, sulfonilamide, TMP/SMX, Trefouel | Leave a reply

Sesquicentennial of the Clinical Thermometer

Posted on May 31, 2016 by Harald — No Comments ↓

The history of the thermometer is studded with famous and familiar names. Galileo Galilei from Pisa, Santorio from Padua, and Huygens from The Hague developed temperature measuring devices, and Celsius from Uppsala, a Swede with a latinized name, Fahrenheit, from Continue reading Sesquicentennial of the Clinical Thermometer→

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Posted in Did you know...?, The News, The Viewpoint | Tagged Aitken, Allbutt, antibiotic blog, Celsius, clinical thermometer, Fahrenheit, fever, fever types, Galileo, Harald Reinhart, Huygens, Kelvin, normal temperature, Reaumur, temperature variation in health and disease, thermometry, Traube, Wunderlich | Leave a reply

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Posts and Blogs

A Critical Review of WHO’s List of Antibacterials in Clinical Development
Some Thoughts about the New Coronavirus Syndrome and its Transmission
Connections: From Mima/Herellea to Acinetobacter to the Double Helix to Lwoff to … CRAB
The Weak Correlation Between Antibiotic Action and Mortality
FDA Needs Radical Reform
The Letermovir Top-Line Results are Out – Or Are They?
The CDC and Spectinomycin
GC Therapy – Shooting for the Stars
Efficacy and Treatment Duration: Where is the Tipping Point?
QIDP, a Liberal Hand-Out from FDA

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