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Growth Promotion Now Called Prophylaxis – The Logic of Chicks

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California is getting rid of a time-honored justification for antibiotic use in veterinary medicine [1].  No longer will it be acceptable to prescribe them for  ”growth promotion”, but rather only for “prophylaxis”.  Just like in humans, so it is argued, does prudent use of antibiotics have a place in prevention, Continue reading Growth Promotion Now Called Prophylaxis – The Logic of Chicks→

The Futile Quest of Proofing a Negative in the Presence of Overwhelming Absence of Harm

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The cartilage damage caused by fluoroquinolones in juvenile beagle dogs is not subtle:  blister formation and erosions occur in a dose-dependent fashion resulting in reversible cartilage damage.  These lesions can be seen not just histologically but even macroscopically.  The animals are unable to walk as weight-bearing joints are predominantly affected.  Continue reading The Futile Quest of Proofing a Negative in the Presence of Overwhelming Absence of Harm→

Following The Publication Trail of Two RSV Drugs

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In a publication from 2007, investigators from Arrow Pharmaceuticals told us that A-60444 (later renamed to RSV-604) was already in Phase 2.  Since then, it has been very quiet about this compound.  Some have suggested that Novartis has stopped development [1], an impression supported by the fact that the drug is Continue reading Following The Publication Trail of Two RSV Drugs→