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Tag Archives: EMEA

Dosis Sola Facit Venenum – The TAB08 (aka TGN1412) Relaunch

Posted on June 4, 2015 by Harald — No Comments ↓

It is a while ago (2006) when TeGenero ran its ill-fated Phase 1 study of TGN1412, a CD28 superagonist slated for studies in diseases like rheumatoid arthritis and B-cell CLL. Unexpectedly, in this FIM study, TGN1412 generated a cytokine release syndrome (CRS), some called it “cytokine storm”, a massive T-cell Continue reading Dosis Sola Facit Venenum – The TAB08 (aka TGN1412) Relaunch→

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Posted in Did you know...?, Recent Literature | Tagged acne, allometric scaling, antibiotic blog, CD28 receptor, cytokine release syndrome, cytokine storm, dose-response, EMEA, endotoxin release, MABEL, minimal anticipated biological effect level, multiple myeloma, no adverse effect level, NOAEL, non-predictive preclinical models, Paracelsus, retinoids, T-cell superagonist, TAB08, TeGenero, TGN-1412, thalidomide, TheraMAB, toxemia | Leave a reply

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