Prof Brambell’s FcRn – The Story So Far

Francis William Rogers Brambell was an Irish scientist who rose to prominence in the middle of the last century.  He is remembered for 2 major accomplishments.  First and foremost, his discovery that passive immunity is transferred from mother to baby.  Continue reading Prof Brambell’s FcRn – The Story So Far

Dosis Sola Facit Venenum – The TAB08 (aka TGN1412) Relaunch

It is a while ago (2006) when TeGenero ran its ill-fated Phase 1 study of TGN1412, a CD28 superagonist slated for studies in diseases like rheumatoid arthritis and B-cell CLL. Unexpectedly, in this FIM study, TGN1412 generated a cytokine release Continue reading Dosis Sola Facit Venenum – The TAB08 (aka TGN1412) Relaunch