Following The Publication Trail of Two RSV Drugs

In a publication from 2007, investigators from Arrow Pharmaceuticals told us that A-60444 (later renamed to RSV-604) was already in Phase 2.  Since then, it has been very quiet about this compound.  Some have suggested that Novartis has stopped development [1], an impression supported by the fact that the drug is Continue reading Following The Publication Trail of Two RSV Drugs

Not So Boring:  Boron-Containing Antibiotics Create a Stir

Why are there so few boron-containing drugs on the market?  The cancer drug bortezumib (Velcade®) may be the only better-known drug on the market with a boron atom in its structure.[1]  Among antibiotics, there is Kerydin™ (tavaborole), an approved topical solution for the treatment of onychomycosis caused by Trichophyton but Continue reading Not So Boring:  Boron-Containing Antibiotics Create a Stir

Some Curious Tidbits

Were you aware that… there is also an amphotericin A which has antifungal properties?  It has a broader spectrum but is much less potent than Amphotericin B and therefore not being used. [1] in 1946, the first truly randomized and partially blinded study was started in Britain under the leadership of the Continue reading Some Curious Tidbits