Allphase Pharma Consulting, LLC
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Shortly after Domagk and Hörlein announced their discovery of the antibacterial properties of the dye sulfamidochrysoidine (Prontosil) in 1935, numerous chemical companies set out to modify the chemical structure. They soon recognized the sulfa component as the true antibacterial and produced an incredible number of derivatives (more than 5000 different compounds!!) by 1945.[1, Continue reading The Rapid Rise of Sulfonamide Diversity
Sulfonamides really cover more infectious territory than most other antibiotics. Besides the more common bacterial species, they are active against many ‘special’ pathogens, like S. maltophilia, P. jiroveci, Listeria, Nocardia,, C. burneti (Q-fever), and T. whipplei (Whipple’s disease). Not to forget their use in malaria, toxoplasmosis, melioidosis, cyclospora, and atypical mycobacterial infections. Then there Continue reading The Amazing Sulfonamides
It’s becoming a daunting task to follow the field given the rapid-fire release of study results and the many recent submissions of new direct-acting antiviral (DAA) drugs. All will be given as cocktails, with or without interferon or ribavirin, and for various durations depending on genotype (GT) and other factors. How Continue reading Snapshot: HCV Drugs in Development