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Tag Archives: macrodantin

Nitrofurantoin – An Old Drug Resurrected Needs Prospective Scrutiny

Posted on June 29, 2015 by Harald — No Comments ↓

When older drugs get reintroduced into clinical practice because pathogens have developed resistance to newer agents, it comes at the price of uncertainty. Often, older drugs were approved based on rather limited data, often considered incomplete by today’s standards.  Take colistin as an example: approved in the early 60ies, we still Continue reading Nitrofurantoin – An Old Drug Resurrected Needs Prospective Scrutiny→

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Posted in The News, The Viewpoint | Tagged amoxicillin, antibiotic blog, Cochrane, colistin, colistin dosing, CRE, erythromycin, ESBL, fluoroquinolones, fosfomycin, incomplete data, macrodantin, MDR uropathogens, nitrofurantoin, nitrofurantoin efficacy, nitrofurantoin safety, QTc prolongation, TdP, TMP/SMX, Torsade de pointes, uncomplicated UTI, uropathogenic E. coli, UTI treatment guidelines, uUTI, ventricular arrhythmia | Leave a reply

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