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George Washington, age 67, had a bad peritonsillar or epiglottal abscess; indeed, he died from it as his personal physicians resorted to extensive blood letting and did not dare lance the abscess. He would have recovered with penicillin, I guess, but in his days the best treatment option for quinsy was surgical drainage. Continue reading Strep Infections in High Places
Shortly after Domagk and Hörlein announced their discovery of the antibacterial properties of the dye sulfamidochrysoidine (Prontosil) in 1935, numerous chemical companies set out to modify the chemical structure. They soon recognized the sulfa component as the true antibacterial and produced an incredible number of derivatives (more than 5000 different compounds!!) by 1945.[1, Continue reading The Rapid Rise of Sulfonamide Diversity
Sulfonamides really cover more infectious territory than most other antibiotics. Besides the more common bacterial species, they are active against many ‘special’ pathogens, like S. maltophilia, P. jiroveci, Listeria, Nocardia,, C. burneti (Q-fever), and T. whipplei (Whipple’s disease). Not to forget their use in malaria, toxoplasmosis, melioidosis, cyclospora, and atypical mycobacterial infections. Then there Continue reading The Amazing Sulfonamides