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Development pf antibacterials differs in several important ways from drug development in other areas, and the lack of standard dose-finding is just one of them. Dose-finding in its most basic form involves ascending amounts of drug for efficacy and safety; Continue reading Efficacy and Treatment Duration: Where is the Tipping Point?
Once upon a time – not so long ago – we were taught the following: Streptococcus pneumoniae was the cause of 90% of CAP cases. That statement was later modified to mean S. pneumoniae was the underlying pathogen in 90% of bacterial cases Continue reading The Etiology of CAP Remains Elusive – A Call to Change Antibiotic Prescribing Patterns
The treatment history of N. gonorrhoeae makes for fascinating reading. This organism has always been able to keep the upper hand in the war of bug versus drug. Once susceptible to sulfa drugs, to penicillin, tetracyclines and fluoroquinolones, it sequentially Continue reading A GO / NO GO decision: Delafloxacin Stumbles in Gonorrhea Study
Aeromonas salmonicida causes furunculosis in salmon hatcheries and in freshwater fish. The organism has several recognized virulence mechanisms including the T3SS [1]. Link to this post!
George Washington, age 67, had a bad peritonsillar or epiglottal abscess; indeed, he died from it as his personal physicians resorted to extensive blood letting and did not dare lance the abscess. He would have recovered with penicillin, I guess, but in his Continue reading Strep Infections in High Places