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Inhibitor of the NDM Enzyme Aspergillomarasmine (AMA) was identified as an inhibitor of the New Delhi metallo-betalactamase (NDM) enzyme. This substance, when combined with meropenem, restored antibiotic activity against an NDM lab strain. AMA is a substance which was already tested in the past in humans. Concerns about interference with human metalloenzymes proved Continue reading Perusing the Literature
You are excused if “Pig Progress” or “The Pig Site” are not journals on your regular reading list. So, you may not have heard about the massive recent culling of swine in Russia in response to outbreaks of ASF (African swine fever). ASF is a severe hemorrhagic disease associated with mortality Continue reading African Swine Fever Epidemics in Russia
The economics of developing antibacterials is a frustrating topic to address. There are unique aspects to the antibiotic market which sets it apart from other medicines, esp. the unique societal aspects of antibiotic use which go beyond the benefit to the individual. IDSA has spoken out in various publications (“Bad Continue reading It’s Not a Free-Enterprise Market, Stupid!