Sesquicentennial of the Clinical Thermometer

The history of the thermometer is studded with famous and familiar names. Galileo Galilei from Pisa, Santorio from Padua, and Huygens from The Hague developed temperature measuring devices, and Celsius from Uppsala, a Swede with a latinized name, Fahrenheit, from the Hanseatic city of Danzig, now in Poland, René Antoine Continue reading Sesquicentennial of the Clinical Thermometer

Multiple Choice Frustrations

Periodically – maybe in preparation for Specialty Board exams – we all work through some test modules graciously provided at the ABIM website. These test questions are in multiple choice format just as one would find in the actual exam. They are produced by specialists in their respective fields; there is Continue reading Multiple Choice Frustrations

AZD-0914: A New Broad-Spectrum Narrow-Development Path Drug

At first glance, the list of features that distinguish AZD-0914 from other FQ seems impressive: broad Gram-positive and Gram-negative activity, MRSA and MSSA activity, potency against fluoroquinolone (FQ)-resistant isolates, low frequency for S. aureus resistance, and impressive activity against C. difficile. In addition, researchers mention a peculiar MoA for this gyrase/topoisomerase Continue reading AZD-0914: A New Broad-Spectrum Narrow-Development Path Drug