At Last, The Fairy Tale Becomes Clear…

If you ever wondered how Snow White could have been poisoned by eating an apple, you probably did not realize how much this tale of folklore was based on cruel reality.  Science has finally caught up with the Brothers Grimm who wrote the fairy tale:  a recent outbreak of listeriosis Continue reading At Last, The Fairy Tale Becomes Clear…

The Circuitous Route to Phase 3:  Another Chapter in the Fitful Development of PTK-0796

When antibiotics change hands, it can be a good thing.  Small companies are often desperate to attract a partner with ‘deep pockets’ to help them finance an expensive late phase development but often have to give up control once the honeymoon period is over.  Such transitions can bring delays because new Continue reading The Circuitous Route to Phase 3:  Another Chapter in the Fitful Development of PTK-0796

After Harvoni: What’s Still Left to Improve (Besides the Price Tag)?

SVR rates in recent DAA combination trials are really impressive.  Hardly a month goes by without yet another trial showing excellent efficacy in populations so far considered ‘difficult to treat’, like cirrhotics or post-liver transplant patients on immunosuppressive therapies.  This begs the question: is there still room for improvement?  Why Continue reading After Harvoni: What’s Still Left to Improve (Besides the Price Tag)?