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Tag Archives: MEDI-4893

AZD-0914: A New Broad-Spectrum Narrow-Development Path Drug

Posted on May 12, 2016 by Harald — No Comments ↓

At first glance, the list of features that distinguish AZD-0914 from other FQ seems impressive: broad Gram-positive and Gram-negative activity, MRSA and MSSA activity, potency against fluoroquinolone (FQ)-resistant isolates, low frequency for S. aureus resistance, and impressive activity against C. difficile. In addition, researchers mention a peculiar MoA for this gyrase/topoisomerase Continue reading AZD-0914: A New Broad-Spectrum Narrow-Development Path Drug→

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Posted in QIDP Antibiotics, The News, The Viewpoint | Tagged ABSSSI, Achaogen, anti-staphylococcal monoclonal antibody, antibiotic blog, AstraZeneca, AZD-0914, CABP, delafloxacin, Entasis, eravacycline, ETX-0914, FoM, frequency of mutation, GC, gepoticidin, GSK, GSK-2140944, gyrase inhibitor, Harald Reinhart, MEDI-4893, MedImmune, Melinta, MoA, MRSA, MSSA, N. gonorrhoeae, plazomicin, QIDP, Tetraphase, topoisomerase II inhibitor, VABP, VABP prophylaxis, Zoliflodacin | Leave a reply

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