PK/PD of BIOLOGICALS

Sometimes we come across an article we wish we had read earlier.  This was the case with the publication by Zhao and colleagues[1].  The article, now more than 12 years old, was written in the ‘early’ days of biological drug development, after the first wave of mAbs had already been Continue reading PK/PD of BIOLOGICALS

NANOBODIES FOR AUTOIMMUNE DISEASES

Thrombotic thrombocytopenic purpura (TTP) is a devastating disease with a downhill course of neurologic, renal and cardiac complications leading to death at a young age if untreated.  Thrombocytopenia and thrombosis are its hallmark, with fever, anemia and neurologic deficits. It is caused by large aggregates of vWF, a protein which Continue reading NANOBODIES FOR AUTOIMMUNE DISEASES

About A Prepared Mind – In R&D

“Chance favors the prepared mind” is the short form of a statement by Louis Pasteur which actually reads: “In the fields of observation chance favours only the prepared mind” or ” Dans les champs de l’observation le hasard ne favorise que les esprits prepares”. [1] There is no better example Continue reading About A Prepared Mind – In R&D