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Some Thoughts about Eravacycline Based on the Phase 2 cIAI Study

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Solomkin et al. conclude that the efficacy and safety of eravacycline compares favorably to the control drug, ertapenem.[1]  This top-level assessment is made with the usual caveats (insufficient statistical power, small sample size), but a few points deserve comment. Eravacycline is a fluorocycline; as a tetracycline derivative it follows into Continue reading Some Thoughts about Eravacycline Based on the Phase 2 cIAI Study→

Learning from Set-Backs: The Frustrating Search for a Staphylococcal Vaccine

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Several reasons have been proposed as explanations why so many S. aureus vaccines have failed in clinical trials.  Clearly, the organism has a battery of virulence factors which may require a multipronged approach and neutralizing just a single mechanism with a specific mAb may not suffice.

Ebola – Fact Sheet (Updated 10/3/2014)

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The WHO just released the latest statistics on what has turned into the largest ever outbreak of Ebola virus (EBOV) in Africa.  The epidemic started in Guinea around December 2013. As of 7/27/2014, Guinea, Liberia, Nigeria, and Sierra Leone have reported a total of 1323 cases, with 729 fatalities [i].  Most Continue reading Ebola – Fact Sheet (Updated 10/3/2014)→