What is the “Niche” for Ceftolozane / Tazobactam?

There are currently a total of 6 beta-lactam + beta-lactamase inhibitor combinations in clinical trials. It will be a steep learning curve for the pharma reps (and physicians) to understand the resistance classifications, the confusing ESBL definitions, the CRE nomenclature, and how this all matters in clinical practice, on the Continue reading What is the “Niche” for Ceftolozane / Tazobactam?

Antibiotics with Ocular Toxicity

The recent discussion whether fluoroquinolones (FQ) cause retinal detachment was short-lived and soon put to rest.   The issue was raised by 2 observational studies but no signal was seen in a larger and better designed  Danish study.  So it seems the association is probably spurious [i].

Greenwood: Antimicrobial Drugs – Chronicle of a Twentieth Century Medical Triumph

This is not meant to be a book review.  I just want to express my gratitude to Prof. Greenwood for writing a book about the remarkable story of antibiotic discovery and development of the last century.  It is clearly a labor of love, written with knowledge, enthusiasm, wisdom and perspective.