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Aztreonam PLUS Avibactam – A New Bright Star in the Night Sky

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Looking at the molecular structure of ceftazidime (CTAZ) and aztreonam (ATM), the differences are clear, and so are the similarities: ATM does not have the cephem ring structure of CTAZ, only the 4-member beta-lactam ring.  However, the side chains are identical in both CTAZ and ATM which explains the overlapping Continue reading Aztreonam PLUS Avibactam – A New Bright Star in the Night Sky→

Ibuprofen For uUTI: Interesting Pilot Trial But More to Come Soon

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At the recent AMDAC, the frequent mention of an unusual uUTI study caught my attention.  In their review of placebo-controlled trials, FDA mentioned a study comparing ciprofloxacin with Ibuprofen (Motrin), an NSAID drug without any antibacterial activity[1].  By the outcome of total symptom relief, there was no difference. Obviously, there Continue reading Ibuprofen For uUTI: Interesting Pilot Trial But More to Come Soon→

The FDA AMDAC on Fluoroquinolones (Part 2): Where Were the FQ Advocates?

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Any FDA meeting is a high-stakes game for industry:  One never knows how the discussions will go. Some oddball issue may take center stage and usurp much time, creating an unbalanced perspective.  At other times, simple issues seem to create controversy, questions are not properly understood in the context of Continue reading The FDA AMDAC on Fluoroquinolones (Part 2): Where Were the FQ Advocates?→