Tag Archives: itraconazole

Cresemba / Isavuconazole:  Not Just Another Azole

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It is amazing how modifications to the azole structure have produced ever more potent, ever more useful antifungals.  Ketoconazole had limited usability because of its many side effects related to off-target sterol synthesis inhibition, solubility (or lack thereof) and erratic absorption.  Solublity was also an issue for itraconazole and posaconazole.  Continue reading Cresemba / Isavuconazole:  Not Just Another Azole→

Nikkomycins Are Finally Getting Some Respect

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Besides azoles, candins and the polyene class of antifungals there is not much to select from when it comes to systemic fungal infections.  Until the recent arrival of voriconazole and posaconazole, infections caused by molds always required amphotericin B to control.  Only for Candida several good treatments exist on the Continue reading Nikkomycins Are Finally Getting Some Respect→

The Amazing Sulfonamides

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Sulfonamides really cover more infectious territory than most other antibiotics. Besides the more common bacterial species, they are active against many ‘special’ pathogens, like S. maltophilia, P. jiroveci, Listeria, Nocardia,, C. burneti (Q-fever), and T. whipplei (Whipple’s disease). Not to forget their use in malaria, toxoplasmosis,  melioidosis, cyclospora, and atypical mycobacterial infections. Then there Continue reading The Amazing Sulfonamides→