Tag Archives: maribavir

The Letermovir Top-Line Results are Out – Or Are They?

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Usually, as development progresses from preclinical to a more advanced clinical stage, reality begins to set in: problems become apparent that were not anticipated, efficacy may be less than expected or hoped for, and the safety margins may shrink to a single-digit factor. In other words, as more data accrue, Continue reading The Letermovir Top-Line Results are Out – Or Are They?→

Brincidofovir – Another Drug Fails in Phase 3

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It is sad to see a pivotal trial fail, and you have to wonder why we recently had several such late-stage ‘mishaps’. Take Tetraphase’s eravacycline which failed in a Phase 3 cUTI trial. We have analyzed this drug’s failure in earlier blogs; there is reason to believe that inadequate dosing was Continue reading Brincidofovir – Another Drug Fails in Phase 3→