Prof Brambell’s FcRn – The Story So Far

Francis William Rogers Brambell was an Irish scientist who rose to prominence in the middle of the last century.  He is remembered for 2 major accomplishments.  First and foremost, his discovery that passive immunity is transferred from mother to baby.  Based on research in various animal species on the transfer Continue reading Prof Brambell’s FcRn – The Story So Far

Dosis Sola Facit Venenum – The TAB08 (aka TGN1412) Relaunch

It is a while ago (2006) when TeGenero ran its ill-fated Phase 1 study of TGN1412, a CD28 superagonist slated for studies in diseases like rheumatoid arthritis and B-cell CLL. Unexpectedly, in this FIM study, TGN1412 generated a cytokine release syndrome (CRS), some called it “cytokine storm”, a massive T-cell Continue reading Dosis Sola Facit Venenum – The TAB08 (aka TGN1412) Relaunch