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IV Fosfomycin To The Rescue – And To a Place Near You

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A recent letter to the Editor by Simkins et al. is worth reviewing [1]. The authors describe the complicated course of a patient who suffered graft rejection after liver transplantation, received broad-spectrum antibiotics during prolonged hospitalization and eventually had a bloodstream infection with carbapenem-resistant Klebsiella pneumoniae (CRKP) which was resistant Continue reading IV Fosfomycin To The Rescue – And To a Place Near You→

Aztreonam PLUS Avibactam – A New Bright Star in the Night Sky

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Looking at the molecular structure of ceftazidime (CTAZ) and aztreonam (ATM), the differences are clear, and so are the similarities: ATM does not have the cephem ring structure of CTAZ, only the 4-member beta-lactam ring.  However, the side chains are identical in both CTAZ and ATM which explains the overlapping Continue reading Aztreonam PLUS Avibactam – A New Bright Star in the Night Sky→

Polyphor POL7080 And The Journey to The Land of Pyocyanea  (Part 1)

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When Roche inlicensed Polyphor’s anti-pseudomonas drug POL7080 in November 2013, it marked a turning point. It seemed that Big Pharma that had all but abandoned the field in the last decade and was getting engaged in anti-infectives again. When a company with as much experience in antibiotic drug development as Roche Continue reading Polyphor POL7080 And The Journey to The Land of Pyocyanea  (Part 1)→