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A GO / NO GO decision:  Delafloxacin Stumbles in Gonorrhea Study

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The treatment history of N. gonorrhoeae makes for fascinating reading.  This organism has always been able to keep the upper hand in the war of bug versus drug.  Once susceptible to sulfa drugs, to penicillin, tetracyclines and fluoroquinolones, it sequentially become resistant in the matter of a decade to every Continue reading A GO / NO GO decision:  Delafloxacin Stumbles in Gonorrhea Study→

Antibiotics with Ocular Toxicity

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The recent discussion whether fluoroquinolones (FQ) cause retinal detachment was short-lived and soon put to rest.   The issue was raised by 2 observational studies but no signal was seen in a larger and better designed  Danish study.  So it seems the association is probably spurious [i].

Aeromonas salmonicida: Trouble for Aquaculture with Drug Resistance

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Aeromonas salmonicida causes furunculosis in salmon hatcheries and in freshwater fish.  The organism has several recognized virulence mechanisms including the T3SS [1].