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This December, Achaogen released much data on 2 plazomicin trials[1]: the pivotal EPIC study comparing plazomicin / levofloxacin with meropenem / levofloxacin in cUTI is the one we want to look at today because it is interpretable, while the other trial Continue reading All Smiles at the Press Conference: Plazo+Levo Delivers
Now, I know we should not make light of any IDSA Guidelines, far from it. This latest, the Aspergillus Guideline [1], like others before, is a thoughtful document which reviews the newest information and reflects expert authoritative thinking on the Continue reading Aspergillus_Guideline.ZIP
Vancomycin got a bad reputation since the early 90ies when it became clear that it was slow to provide clinical improvement and microbiologic cure in MRSA patients. It was associated with prolonged bacteremia even when combined with rifampin [1]. And for MSSA, Continue reading Vancomycin vs TMP/SMX for MRSA – Not the Final Word
Searching data on antibiotic use in surgery prophylaxis, I came across an article from the Mayo Clinic [1]. The authors mention that approx. 75% of patients that developed surgical site infections did not get proper antibiotic prophylaxis. Errors were made in (1) Continue reading No Easy Day: Dose Calculations for Aminoglycosides and Vancomycin