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SIRS, sepsis, severe sepsis, septic shock is a continuum, a crescendo of signs and symptoms associated with an infection uncontrolled by host responses. An avalanche or cascade of seemingly unstoppable events occurs often in a matter of hours which has defied causal intervention but for which symptomatic treatment has improved Continue reading Recent Sepsis Literature
A recent letter to the Editor by Simkins et al. is worth reviewing [1]. The authors describe the complicated course of a patient who suffered graft rejection after liver transplantation, received broad-spectrum antibiotics during prolonged hospitalization and eventually had a bloodstream infection with carbapenem-resistant Klebsiella pneumoniae (CRKP) which was resistant Continue reading IV Fosfomycin To The Rescue – And To a Place Near You
It is sad to see a pivotal trial fail, and you have to wonder why we recently had several such late-stage ‘mishaps’. Take Tetraphase’s eravacycline which failed in a Phase 3 cUTI trial. We have analyzed this drug’s failure in earlier blogs; there is reason to believe that inadequate dosing was Continue reading Brincidofovir – Another Drug Fails in Phase 3