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IV Fosfomycin To The Rescue – And To a Place Near You

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A recent letter to the Editor by Simkins et al. is worth reviewing [1]. The authors describe the complicated course of a patient who suffered graft rejection after liver transplantation, received broad-spectrum antibiotics during prolonged hospitalization and eventually had a bloodstream infection with carbapenem-resistant Klebsiella pneumoniae (CRKP) which was resistant Continue reading IV Fosfomycin To The Rescue – And To a Place Near You→

Food for Thought, Sprinkled With Small Amounts of Antibiotic Residues

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80% of antibiotics worldwide are used in veterinary medicine. With only a minor fraction metabolized to inactive compounds, there are plenty of antibiotics excreted by farm animals in unchanged active form. These antibiotic residues are found in manure, in the soil onto which manure is sprayed, tilled in, or in the Continue reading Food for Thought, Sprinkled With Small Amounts of Antibiotic Residues→

Nitrofurantoin – An Old Drug Resurrected Needs Prospective Scrutiny

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When older drugs get reintroduced into clinical practice because pathogens have developed resistance to newer agents, it comes at the price of uncertainty. Often, older drugs were approved based on rather limited data, often considered incomplete by today’s standards.  Take colistin as an example: approved in the early 60ies, we still Continue reading Nitrofurantoin – An Old Drug Resurrected Needs Prospective Scrutiny→