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No Easy Day: Dose Calculations for Aminoglycosides and Vancomycin

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Searching data on antibiotic use in surgery prophylaxis, I came across an article from the Mayo Clinic [1].  The authors mention that approx. 75% of patients that developed surgical site infections did not get proper antibiotic prophylaxis.  Errors were made in (1) selection of the antibiotic, (2) timing of administration, (3) antibiotic Continue reading No Easy Day: Dose Calculations for Aminoglycosides and Vancomycin→

Cresemba / Isavuconazole:  Not Just Another Azole

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It is amazing how modifications to the azole structure have produced ever more potent, ever more useful antifungals.  Ketoconazole had limited usability because of its many side effects related to off-target sterol synthesis inhibition, solubility (or lack thereof) and erratic absorption.  Solublity was also an issue for itraconazole and posaconazole.  Continue reading Cresemba / Isavuconazole:  Not Just Another Azole→

The Pneumococcus, Prominent Microbiologists, Contributions and Cross-Connections

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‘He who knows syphilis knows medicine’ goes the saying. In a similar way this adage could be applied to the Pneumococcus, aka Streptococcus pneumoniae, Diplococcus pneumoniae or Diplococcus lanceolatus by saying “He who knows S. pneumoniae knows microbiology”. Many ‘big names’ studied the organism.  Their work on the Pneumococcus led to Continue reading The Pneumococcus, Prominent Microbiologists, Contributions and Cross-Connections→