What is the “Niche” for Ceftolozane / Tazobactam?

There are currently a total of 6 beta-lactam + beta-lactamase inhibitor combinations in clinical trials. It will be a steep learning curve for the pharma reps (and physicians) to understand the resistance classifications, the confusing ESBL definitions, the CRE nomenclature, and how this all matters in clinical practice, on the Continue reading What is the “Niche” for Ceftolozane / Tazobactam?

Antibiotics with Ocular Toxicity

The recent discussion whether fluoroquinolones (FQ) cause retinal detachment was short-lived and soon put to rest.   The issue was raised by 2 observational studies but no signal was seen in a larger and better designed  Danish study.  So it seems the association is probably spurious [i].

Surprise: Hanta Virus Right in Your Back Yard

Hanta Virus Epidemics in Germany? When I learned that a friend of mine came down with Hanta virus infection in Germany, I thought I had heard wrong. Mice and voles shed hanta viruses in their excreta which – when aerosolized and inhaled – can cause significant disease.  In some parts Continue reading Surprise: Hanta Virus Right in Your Back Yard