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Growth Promotion Now Called Prophylaxis – The Logic of Chicks

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California is getting rid of a time-honored justification for antibiotic use in veterinary medicine [1].  No longer will it be acceptable to prescribe them for  ”growth promotion”, but rather only for “prophylaxis”.  Just like in humans, so it is argued, does prudent use of antibiotics have a place in prevention, Continue reading Growth Promotion Now Called Prophylaxis – The Logic of Chicks→

The Futile Quest of Proofing a Negative in the Presence of Overwhelming Absence of Harm

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The cartilage damage caused by fluoroquinolones in juvenile beagle dogs is not subtle:  blister formation and erosions occur in a dose-dependent fashion resulting in reversible cartilage damage.  These lesions can be seen not just histologically but even macroscopically.  The animals are unable to walk as weight-bearing joints are predominantly affected.  Continue reading The Futile Quest of Proofing a Negative in the Presence of Overwhelming Absence of Harm→

What is the “Niche” for Ceftolozane / Tazobactam?

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There are currently a total of 6 beta-lactam + beta-lactamase inhibitor combinations in clinical trials. It will be a steep learning curve for the pharma reps (and physicians) to understand the resistance classifications, the confusing ESBL definitions, the CRE nomenclature, and how this all matters in clinical practice, on the Continue reading What is the “Niche” for Ceftolozane / Tazobactam?→