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Treating GC in the Face of Dwindling Antibiotic Options – (1)

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Looking across the Northern border it is clear that CDC Guidelines are not universally followed even in North America. Public Health Canada still recommends cefixime for uncomplicated gonorrhea (GC), albeit at the high single oral dose of 800 mg [1]. In the US, CDC has opted for combination treatment with ceftriaxone Continue reading Treating GC in the Face of Dwindling Antibiotic Options – (1)→

A GO / NO GO decision:  Delafloxacin Stumbles in Gonorrhea Study

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The treatment history of N. gonorrhoeae makes for fascinating reading.  This organism has always been able to keep the upper hand in the war of bug versus drug.  Once susceptible to sulfa drugs, to penicillin, tetracyclines and fluoroquinolones, it sequentially become resistant in the matter of a decade to every Continue reading A GO / NO GO decision:  Delafloxacin Stumbles in Gonorrhea Study→

The Futile Quest of Proofing a Negative in the Presence of Overwhelming Absence of Harm

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The cartilage damage caused by fluoroquinolones in juvenile beagle dogs is not subtle:  blister formation and erosions occur in a dose-dependent fashion resulting in reversible cartilage damage.  These lesions can be seen not just histologically but even macroscopically.  The animals are unable to walk as weight-bearing joints are predominantly affected.  Continue reading The Futile Quest of Proofing a Negative in the Presence of Overwhelming Absence of Harm→