Tag Archives: CMV prophylaxis

CMV Connections: Paul-Bunnell Negative Mononucleosis and ‘Changelings’

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Mononuclesosis is an EBV infection that can be diagnosed with the heterophil antibody test developed by Paul and Bunnell. The test is based on the agglutination of sheep erythrocytes with the blood of EBV infected patients. P-B heterophil serology is negative in ‘mononucleosis’ caused by CMV. In this day and Continue reading CMV Connections: Paul-Bunnell Negative Mononucleosis and ‘Changelings’→

The Monoclonal Pursuit of the Next CMV Therapeutic

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There is no doubt that immunity to human cytomegalovirus (CMV) is both cell-and antibody-mediated. Studies in transplant patients showed that absence of T-cell protection with chemotherapy is a set-up for recurrent and severe CMV disease. It was also shown that patients with pre-existing CMV antibodies are less likely to develop CMV Continue reading The Monoclonal Pursuit of the Next CMV Therapeutic→