Lung Ultrasound has Come a Long Way

The old-fashioned portable chest X-ray is still the preferred way of documenting pneumonia at the bedside. Although more cumbersome, CT scans are also frequently employed for more definitive diagnosis, esp. in the ER or the ICU setting. Historically, ultrasound of the lungs (LUS) was always problematic as the sound waves do Continue reading Lung Ultrasound has Come a Long Way

Sesquicentennial of the Clinical Thermometer

The history of the thermometer is studded with famous and familiar names. Galileo Galilei from Pisa, Santorio from Padua, and Huygens from The Hague developed temperature measuring devices, and Celsius from Uppsala, a Swede with a latinized name, Fahrenheit, from the Hanseatic city of Danzig, now in Poland, René Antoine Continue reading Sesquicentennial of the Clinical Thermometer

AZD-0914: A New Broad-Spectrum Narrow-Development Path Drug

At first glance, the list of features that distinguish AZD-0914 from other FQ seems impressive: broad Gram-positive and Gram-negative activity, MRSA and MSSA activity, potency against fluoroquinolone (FQ)-resistant isolates, low frequency for S. aureus resistance, and impressive activity against C. difficile. In addition, researchers mention a peculiar MoA for this gyrase/topoisomerase Continue reading AZD-0914: A New Broad-Spectrum Narrow-Development Path Drug