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Connections: From Mima/Herellea to Acinetobacter to the Double Helix to Lwoff to … CRAB

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There once was a Scientific American section authored by science historian James Burke called ‘Connections”. In it James Burke, a true renaissance man, showed us how an ‘internet’ of serendipitous encounters, connections between persons, places and events led to advances in science. His delightful tours through history are testimony to Continue reading Connections: From Mima/Herellea to Acinetobacter to the Double Helix to Lwoff to … CRAB→

CMV Connections: Paul-Bunnell Negative Mononucleosis and ‘Changelings’

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Mononuclesosis is an EBV infection that can be diagnosed with the heterophil antibody test developed by Paul and Bunnell. The test is based on the agglutination of sheep erythrocytes with the blood of EBV infected patients. P-B heterophil serology is negative in ‘mononucleosis’ caused by CMV. In this day and Continue reading CMV Connections: Paul-Bunnell Negative Mononucleosis and ‘Changelings’→

Prospecting for New Antibiotics

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The QIDP designation was introduced in 2012 to incentivize drug development in antiinfectives. QIDP came with several attractive features, such as prolongation of patent life, FDA expedited review and more.  In addition, FDA made it quite easy to garner the label.  As you can see, there is really no downside to Continue reading Prospecting for New Antibiotics→