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Progress Report: New Antibacterials In the Fight against MDR Bacteria

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Since the beginning of this millennium we have seen antibiotic R&D dwindle year after year. There are many reasons for this; while economics are often cited for this decline, the FDA and the ‘Guideline Wars’, i.e., those never ending discussions about regulatory requirements, have contributed to this trend in a Continue reading Progress Report: New Antibacterials In the Fight against MDR Bacteria→

Lung Ultrasound has Come a Long Way

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The old-fashioned portable chest X-ray is still the preferred way of documenting pneumonia at the bedside. Although more cumbersome, CT scans are also frequently employed for more definitive diagnosis, esp. in the ER or the ICU setting. Historically, ultrasound of the lungs (LUS) was always problematic as the sound waves do Continue reading Lung Ultrasound has Come a Long Way→

Solithromycin CAP Study:  Cap the Details (in the Publication)

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In a recent publication, the results of a large Phase 3 trial comparing solithromycin with moxifloxacin in the treatment of CAP are presented [1]. As this was a global registration trial, we should refer to the indication as CABP, the current FDA acronym for a very defined entity which has some Continue reading Solithromycin CAP Study:  Cap the Details (in the Publication)→