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Some Thoughts about the New Coronavirus Syndrome and its Transmission

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First and upfront, let’s call this virus WARS*, which stands for Wuhan Associated Respiratory Syndrome.  President Xi Jingping called for a war against the new virus, and a war it is.  Therefore our acronym makes intuitive sense.  The naming of new viruses is getting politized and silly: yes, we need Continue reading Some Thoughts about the New Coronavirus Syndrome and its Transmission→

Connections: From Mima/Herellea to Acinetobacter to the Double Helix to Lwoff to … CRAB

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There once was a Scientific American section authored by science historian James Burke called ‘Connections”. In it James Burke, a true renaissance man, showed us how an ‘internet’ of serendipitous encounters, connections between persons, places and events led to advances in science. His delightful tours through history are testimony to Continue reading Connections: From Mima/Herellea to Acinetobacter to the Double Helix to Lwoff to … CRAB→

The Weak Correlation Between Antibiotic Action and Mortality

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At the recent FDA workshop on narrow-spectrum antibiotic development[1], the concept of using bacteriological response (BR) as an efficacy endpoint was flat-out rejected. The reason given is the purported lack of correlation between BR and survival/mortality which FDA considers the most important clinical endpoint[2]. FDA felt so strongly about this, Continue reading The Weak Correlation Between Antibiotic Action and Mortality→