Tag Archives: Contrafect

A Critical Review of WHO’s List of Antibacterials in Clinical Development

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WHO compiles a list of antibacterials in clinical development on a regular basis, the last in mid-2024 [1].  The information is up-to-date and detailed: it provides MoA and antibacterial spectrum, coverage of problem pathogens, the development phase, and whether it can be considered an ‘innovative’ drug (based on a set Continue reading A Critical Review of WHO’s List of Antibacterials in Clinical Development→

Clinical Biofilm Studies – An Interesting Evolving Landscape

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A recent article on “Agents that Prevent Biofilm Formation” captured my interest[1].  The authors reviewed the literature and mentioned many substances which have shown in-vitro efficacy in disrupting biofilm production by the main offenders, i.e., S. aureus, S. epidermidis, P. aeruginosa and K. pneumoniae. These substances come with very diverse Continue reading Clinical Biofilm Studies – An Interesting Evolving Landscape→