ANTIBIOTIC DEVELOPMENT IN PHARMA IS DEAD – FOR NOW

This is a somewhat nostalgic retro blog.  I was leafing through a book by Vince Andriole called ‘The Quinolones’.[1]  First released in 1988, its third edition is from 2000.  It provided in-depth coverage of quinolone chemistry, PK, microbiology, efficacy and safety.  It was a great review of the large and Continue reading ANTIBIOTIC DEVELOPMENT IN PHARMA IS DEAD – FOR NOW

HANTA & WHAT’S NEXT

By now, we’ve had a chance to brush up on the Hanta virus, esp. the Andes variety which caused a mini-epidemic on the arctic cruise ship MV Hondius.  Named after Hantaan, the river in South Korea where the disease first emerged, we give credit to Dr. Ho Wang Lee, the Continue reading HANTA & WHAT’S NEXT

Ensitrelvir for Covid Prevention: This Emperor Has No Clothes

Just imagine you were tasked to conduct a seasonal flu study in household contacts of a symptomatic index case.  Your intervention may be (your choice): pre-season vaccination, pre-exposure prophylaxis, or some non-anti-infective protective measure such as wearing a face mask, taking a vitamin or analgesic that is believed to confer Continue reading Ensitrelvir for Covid Prevention: This Emperor Has No Clothes