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Quick: What do you associate with the abbreviation ‘TCR’? Does your immunology-trained mind automatically default to ‘T-cell receptor’? Or is your first guess ‘Tissue Cross Reactivity? Our neural networks can deal with ambivalence and will make the right associations, eventually. Language is imprecise by design and allows for wobble. Things Continue reading OFF-TARGET ANTIBODIES
A recent Nature Review Drug Discovery article caught our attention, a review of TIGIT as an IO target and the failed Phase 3 study of tiragolumab which is the TIGIT inhibitor from Roche.[1] The science writer interviewed a group of insiders that had a lead role in the development of Continue reading The Tiragolumab Saga & Tifacogin Flash-Backs
Aulus Cornelius Celsus wrote his famous book ‘De Medicina’ approximately 2000 years ago. Living in the times of Caesar Augustus, little is known about his persona. We are not even sure whether he was a practicing physician. Many of his books were lost but Volume VIII was rediscovered in the Continue reading New BIOMARKER CONSORTIUM PROs